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Secretin receptor

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Title: Secretin receptor  
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Subject: Olfactory receptor, Thrombin receptor, Prostaglandin receptor, Leukotriene receptor, Neurotransmitter receptor
Collection: G Protein Coupled Receptors
Publisher: World Heritage Encyclopedia

Secretin receptor

Secretin receptor
Symbols  ; SR
External IDs IUPHAR: ChEMBL: GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.[1]


  • Interactions 1
  • References 2
  • Further reading 3
  • External links 4


Secretin receptor has been shown to interact with Pituitary adenylate cyclase activating peptide.[2]


  1. ^ Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Recept. Channels 8 (3–4): 189–200.  
  2. ^ Felley, C P; Qian J M; Mantey S; Pradhan T; Jensen R T (Dec 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. (UNITED STATES) 263 (6 Pt 1): G901–7.  

Further reading

  • Ulrich CD, Holtmann M, Miller LJ (1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors". Gastroenterology 114 (2): 382–97.  
  • Felley CP, Qian JM, Mantey S, et al. (1993). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. 263 (6 Pt 1): G901–7.  
  • Ishihara T, Nakamura S, Kaziro Y, et al. (1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor". EMBO J. 10 (7): 1635–41.  
  • Robberecht P, De Neef P, Waelbroeck M, et al. (1988). "Secretin receptors in human pancreatic membranes". Pancreas 3 (5): 529–35.  
  • Chow BK (1995). "Molecular cloning and functional characterization of a human secretin receptor". Biochem. Biophys. Res. Commun. 212 (1): 204–11.  
  • Patel DR, Kong Y, Sreedharan SP (1995). "Molecular cloning and expression of a human secretin receptor". Mol. Pharmacol. 47 (3): 467–73.  
  • Holtmann MH, Hadac EM, Miller LJ (1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors". J. Biol. Chem. 270 (24): 14394–8.  
  • Jiang S, Ulrich C (1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor". Biochem. Biophys. Res. Commun. 207 (3): 883–90.  
  • Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochem. Biophys. Res. Commun. 193 (2): 546–53.  
  • Mark HF, Chow BK (1996). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry". Genomics 29 (3): 817–8.  
  • Vilardaga JP, di Paolo E, de Neef P, et al. (1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin". Biochem. Biophys. Res. Commun. 218 (3): 842–6.  
  • Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & signal transduction 7 (3): 143–50.  
  • Shetzline MA, Premont RT, Walker JK, et al. (1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor". J. Biol. Chem. 273 (12): 6756–62.  
  • Ho PK, Fong RS, Kai HS, et al. (1999). "The human secretin receptor gene: genomic organization and promoter characterization". FEBS Lett. 455 (3): 209–14.  
  • Pang RT, Ng SS, Cheng CH, et al. (1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor". Endocrinology 140 (11): 5102–11.  
  • Chan KY, Pang RT, Chow BK (2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor". Endocrinology 142 (9): 3926–34.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Pang RT, Lee LT, Ng SS, et al. (2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene". Mol. Endocrinol. 18 (2): 471–83.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.  

External links

  • IUPHAR GPCR Database - Secretin receptor
  • secretin receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

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