World Library  
Flag as Inappropriate
Email this Article

Stratum granulosum

Article Id: WHEBN0002750627
Reproduction Date:

Title: Stratum granulosum  
Author: World Heritage Encyclopedia
Language: English
Subject: Stratum spinosum, Stratum lucidum, Integumentary system, Skin, Filaggrin
Collection: Skin Anatomy
Publisher: World Heritage Encyclopedia

Stratum granulosum

Histologic image showing a section of epidermis. Stratum granulosum labeled near center.

The stratum granulosum (or granular layer) is a thin layer of cells in the epidermis.[1] Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer. These cells contain keratohyalin granules, which are filled with histidine- and cystine-rich proteins that appear to bind the keratin filaments together. Therefore, the main function of keratohyalin granules is to bind intermediate keratin filaments together.[2][3]

At the transition between this layer and the corneocytes in the stratum corneum.[3]

Additional images

See also


  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005) Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Page 2. ISBN 0-7216-2921-0.
  2. ^ Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. Page 7. ISBN 1-4160-3185-5.
  3. ^ a b Ovaere P, Lippens S, Vandenabeele P, Declercq W. (2009). "The emerging roles of serine protease cascades in the epidermis". Trends in Biochemical Sciences 34 (9): 453–463.  
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.