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Title: Tfrc  
Author: World Heritage Encyclopedia
Language: English
Subject: Housekeeping gene, Cancer research, HFE (gene), Transferrin receptor
Publisher: World Heritage Encyclopedia


Transferrin receptor (p90, CD71)
PDB rendering based on 1cx8.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Transferrin receptor protein 1 (TfR1) also known as (Cluster of Differentiation 71) (CD71) is a protein that in humans is encoded by the TFRC gene.[1][2] TfR1 is required for iron delivery from transferrin to cells.[3][4]

Clinical significance

CD71 as a potential new target in cases of human leukomia & lymphoma. InatherYs, in Evry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed its efficacy in pre-clinical studies in the therapy of two incurable orphan oncohematological diseases: the adult T cell leukemia (ATLL) caused by HTLV-1 and the Mantle cell lymphoma (MCL).


TFRC has been shown to interact with GABARAP[5] and HFE.[6][7]

See also


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