World Library  
Flag as Inappropriate
Email this Article

TGF beta receptors

Article Id: WHEBN0009506496
Reproduction Date:

Title: TGF beta receptors  
Author: World Heritage Encyclopedia
Language: English
Subject: TGF beta receptors, KLF14, I-SMAD, Nerve growth factor receptor, BAMBI
Publisher: World Heritage Encyclopedia

TGF beta receptors

transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa)
Symbol TGFBR1
Entrez 7046
HUGO 11772
OMIM 190181
RefSeq NM_004612
UniProt P36897
Other data
Locus Chr. 9 q22
transforming growth factor beta, receptor type II (70/80kDa)
Symbol TGFBR2
Alt. symbols MFS2
Entrez 7048
HUGO 11773
OMIM 190182
RefSeq NM_001024847
UniProt P37173
Other data
Locus Chr. 3 p22
transforming growth factor beta, receptor type III
Symbol TGFBR3
Entrez 7049
HUGO 11774
OMIM 600742
RefSeq NM_003243
UniProt Q03167
Other data
Locus Chr. 1 p33-p32

TGFβ receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric.[1] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions.

TGF (Transforming Growth Factor) are involved in paracrine signalling and can be found in many different tissue types, including brain, heart, kidney, liver, and testes. Over-expression of TGF can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease (ESRD). Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.


Three TGF-β receptor types can be distinguished by their structural and functional properties. Receptor types I and II have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping. Both receptor types I and II have a high affinity for TGF-β1 and low affinity for TGF-β2. TGF-β receptor type III has a high affinity for both TGF-β1 and -β2 and in addition TGF-β1.2.[2]



  1. ^ (free full text)
  2. ^

External links

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.