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Title: Tnfrsf14  
Author: World Heritage Encyclopedia
Language: English
Subject: Herpes simplex virus, Tumor necrosis factor receptor, Microphthalmia-associated transcription factor, TRAF2
Publisher: World Heritage Encyclopedia


Tumor necrosis factor receptor superfamily, member 14
PDB rendering based on 1jma.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Tumor necrosis factor receptor superfamily member 14 is a protein that in humans is encoded by the TNFRSF14 gene.[1][2][3] It is also known as "herpesvirus entry mediator" (HVEM).[4]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.[3]

In melanocytic cells TNFRSF14 gene expression may be regulated by MITF.[5]


TNFRSF14 has been shown to interact with TRAF2,[6][7] TNFSF14[8][9] and TRAF5.[6][7]

Clinical relevance

Mutations in this gene have been recurrently been associated to cases of diffuse large B-cell lymphoma.[10][11]


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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