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Title: Tromantadine  
Author: World Heritage Encyclopedia
Language: English
Subject: Edoxudine, Resiquimod, ATC code D06, Imiquimod, Inosine
Collection: Acetamides, Adamantanes, Amines, Anti-Herpes Virus Drugs
Publisher: World Heritage Encyclopedia


Skeletal formula
Ball-and-stick model
Systematic (IUPAC) name
Clinical data
Routes of
CAS Registry Number  N
ATC code D06 J05
PubChem CID:
ChemSpider  Y
Chemical data
Formula C16H28N2O2
Molecular mass 280.406 g/mol

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz. Its performance is similar to aciclovir.

Like rimantadine and amantadine, tromantadine is a derivative of adamantane.


Tromantadine inhibits the early and late events in the virus replication cycle.[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.


  1. ^ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6.  

External links

  • Viru-Merz website

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