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Tromantadine

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Title: Tromantadine  
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Subject: Edoxudine, Resiquimod, ATC code D06, Imiquimod, Inosine
Collection: Acetamides, Adamantanes, Amines, Anti-Herpes Virus Drugs
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Tromantadine

Tromantadine
Skeletal formula
Ball-and-stick model
Systematic (IUPAC) name
N-1-adamantyl-N-[2-(dimethylamino)ethoxy]acetamide
Clinical data
AHFS/Drugs.com
Routes of
administration
Topical
Identifiers
CAS Registry Number  N
ATC code D06 J05
PubChem CID:
ChemSpider  Y
UNII  Y
KEGG  Y
NIAID ChemDB
Chemical data
Formula C16H28N2O2
Molecular mass 280.406 g/mol
 N   

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz. Its performance is similar to aciclovir.

Like rimantadine and amantadine, tromantadine is a derivative of adamantane.

Mechanism

Tromantadine inhibits the early and late events in the virus replication cycle.[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

References

  1. ^ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6.  

External links

  • Viru-Merz website


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