World Library  
Flag as Inappropriate
Email this Article

Tumor necrosis factor-beta

Article Id: WHEBN0007330428
Reproduction Date:

Title: Tumor necrosis factor-beta  
Author: World Heritage Encyclopedia
Language: English
Subject: Tumor necrosis factors
Publisher: World Heritage Encyclopedia

Tumor necrosis factor-beta

Lymphotoxin alpha (TNF superfamily, member 1)
PDB rendering based on 1tnr.
Available structures
PDB Ortholog search: RCSB
LTA Gene
RNA expression pattern

Lymphotoxin-alpha (LT-alpha) is a protein that in humans is encoded by the LTA gene.[1][2]


Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.[3]

In LTα knockout mice, all Peyer's patches and lymph nodes will fail to develop indicating LTα's importance in immunological development.[4]


Lymphotoxin alpha has been shown to interact with LTB.[5][6][7]

See also


Further reading

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.