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Title: Xcl2  
Author: World Heritage Encyclopedia
Language: English
Subject: XCL1, Outline of immunology, CXCL15, CXCL17, Proinflammatory cytokine
Publisher: World Heritage Encyclopedia


chemokine (C motif) ligand 2
Symbol XCL2
Alt. symbols SCYC2, SCM-1b
Entrez 6846
HUGO 10646
OMIM 604828
RefSeq NM_003175
UniProt Q9UBD3
Other data
Locus Chr. 1 q24.2

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1.[1] It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.[2] Its gene is located on chromosome 1 in humans.[3]


  1. ^ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol 155 (1): 203–9.  
  2. ^ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem 273 (26): 16551–4.  
  3. ^ Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett 395 (1): 82–8.  
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