World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0008430387
Reproduction Date:

Title: Ccl7  
Author: World Heritage Encyclopedia
Language: English
Subject: Chemokine, Neurofibroma, Chromosome 17 (human), CC chemokine receptors, MMP2, CCR1
Publisher: World Heritage Encyclopedia


Chemokine (C-C motif) ligand 7

PDB rendering based on 1bo0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function . It is produced by certain tumor cell lines and by macrophages.[1] This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines[2] and is most closely related to CCL2 (previously called MCP1).


CCL7 has been shown to interact with MMP2.[3]


  1. ^ Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines". Biochem. Biophys. Res. Commun. 191 (2): 535–42. PMID 8461011. doi:10.1006/bbrc.1993.1251. 
  2. ^ Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics 21 (2): 403–8. PMID 7916328. doi:10.1006/geno.1994.1283. 
  3. ^ McQuibban, G A; Gong J H; Tam E M; McCulloch C A; Clark-Lewis I; Overall C M (August 2000). "Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3". Science (UNITED STATES) 289 (5482): 1202–6. ISSN 0036-8075. PMID 10947989. doi:10.1126/science.289.5482.1202. 

Further reading

  • Menten P, Wuyts A, Van Damme J (2002). "Monocyte chemotactic protein-3.". Eur. Cytokine Netw. 12 (4): 554–60. PMID 11781181. 
  • Van Damme J, Proost P, Lenaerts JP, Opdenakker G (1992). "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.". J. Exp. Med. 176 (1): 59–65. PMC 2119277. PMID 1613466. doi:10.1084/jem.176.1.59. 
  • Ben-Baruch A, Xu L, Young PR, et al. (1995). "Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3.". J. Biol. Chem. 270 (38): 22123–8. PMID 7545673. doi:10.1074/jbc.270.38.22123. 
  • Opdenakker G, Fiten P, Nys G, et al. (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.". Genomics 21 (2): 403–8. PMID 7916328. doi:10.1006/geno.1994.1283. 
  • Minty A, Chalon P, Guillemot JC, et al. (1993). "Molecular cloning of the MCP-3 chemokine gene and regulation of its expression.". Eur. Cytokine Netw. 4 (2): 99–110. PMID 8318676. 
  • Opdenakker G, Froyen G, Fiten P, et al. (1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines.". Biochem. Biophys. Res. Commun. 191 (2): 535–42. PMID 8461011. doi:10.1006/bbrc.1993.1251. 
  • Combadiere C, Ahuja SK, Van Damme J, et al. (1996). "Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.". J. Biol. Chem. 270 (50): 29671–5. PMID 8530354. doi:10.1074/jbc.270.50.29671. 
  • Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets.". Cytokine 7 (6): 479–82. PMID 8580362. doi:10.1006/cyto.1995.0065. 
  • Daugherty BL, Siciliano SJ, DeMartino JA, et al. (1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor.". J. Exp. Med. 183 (5): 2349–54. PMC 2192548. PMID 8642344. doi:10.1084/jem.183.5.2349. 
  • Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD (1996). "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.". FEBS Lett. 395 (2-3): 277–82. PMID 8898111. doi:10.1016/0014-5793(96)01024-1. 
  • Meunier S, Bernassau JM, Guillemot JC, et al. (1997). "Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy.". Biochemistry 36 (15): 4412–22. PMID 9109648. doi:10.1021/bi9627929. 
  • Polentarutti N, Introna M, Sozzani S, et al. (1997). "Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells.". Eur. Cytokine Netw. 8 (3): 271–4. PMID 9346360. 
  • Bonini JA, Martin SK, Dralyuk F, et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.". DNA Cell Biol. 16 (10): 1249–56. PMID 9364936. doi:10.1089/dna.1997.16.1249. 
  • Nibbs RJ, Wylie SM, Yang J, et al. (1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.". J. Biol. Chem. 272 (51): 32078–83. PMID 9405404. doi:10.1074/jbc.272.51.32078. 
  • Wang JM, Ueda H, Howard OM, et al. (1998). "HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.". J. Immunol. 161 (8): 4309–17. PMID 9780207. 
  • Albini A, Ferrini S, Benelli R, et al. (1998). "HIV-1 Tat protein mimicry of chemokines.". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13153–8. PMC 23742. PMID 9789057. doi:10.1073/pnas.95.22.13153. 
  • Rabin RL, Park MK, Liao F, et al. (1999). "Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling.". J. Immunol. 162 (7): 3840–50. PMID 10201901. 
  • Wedemeyer J, Lorentz A, Göke M, et al. (1999). "Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa.". Gut 44 (5): 629–35. PMC 1727483. PMID 10205198. doi:10.1136/gut.44.5.629. 
  • Blanpain C, Migeotte I, Lee B, et al. (1999). "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.". Blood 94 (6): 1899–905. PMID 10477718. 
  • Jordan NJ, Kolios G, Abbot SE, et al. (1999). "Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells.". J. Clin. Invest. 104 (8): 1061–9. PMC 408573. PMID 10525044. doi:10.1172/JCI6685. 

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.