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Ap1g1

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Ap1g1

Adaptor-related protein complex 1, gamma 1 subunit
PDB rendering based on 1gyu.
Available structures
PDB Ortholog search: RCSB
Identifiers
AP1G1 Gene
RNA expression pattern

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.[1][2]

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

AP1G1 has been shown to interact with RABEP1,[4][5] AP1B1,[2][6][7] Synaptophysin,[8] AP1M1,[6][7] NECAP2,[9] AP1S1[2][6][7] and AP1GBP1.[4][10]

References

Further reading



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