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Title: Amanullin  
Author: World Heritage Encyclopedia
Language: English
Subject: Amatoxin
Publisher: World Heritage Encyclopedia


CAS number 21803-57-6
PubChem 114856
ChemSpider 102814 YesY
Jmol-3D images Image 2
Molecular formula C39H54N10O12S
Molar mass 886.86 g/mol
Appearance Colorless, crystalline solid
Solubility in water Soluble
Solubility in ethanol, methanol Soluble
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Amanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral LD50 of amanullin is approximately 20 mg/kg in mice, however it is non-toxic in humans.


Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]

See also


External links

  • Amatoxins REVISED
  • Poisonous Mushrooms (German)
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