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Apoptosis-antagonizing transcription factor

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Title: Apoptosis-antagonizing transcription factor  
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Subject: Retinoblastoma protein, NeuroD, EMX homeogene, NOBOX, Winged-helix transcription factors
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Apoptosis-antagonizing transcription factor

Apoptosis antagonizing transcription factor
Symbols  ; BFR2; CHE-1; CHE1; DED
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Protein AATF is a protein that in humans is encoded by the AATF gene.[1][2][3] The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.[3]


Apoptosis-antagonizing transcription factor has been shown to interact with Sp1 transcription factor,[4] POLR2J,[2] PAWR[5] and Retinoblastoma protein.[2][6]


  1. ^ Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Maki M, Kainulainen H (Oct 2000). "Identification of novel transcription factor-like gene from human intestinal cells". Biochem Biophys Res Commun 276 (2): 660–6.  
  2. ^ a b c Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (Jun 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J 14 (7): 904–12.  
  3. ^ a b "Entrez Gene: AATF apoptosis antagonizing transcription factor". 
  4. ^ Di Padova, Monica; Bruno Tiziana, De Nicola Francesca, Iezzi Simona, D'Angelo Carmen, Gallo Rita, Nicosia Daniela, Corbi Nicoletta, Biroccio Annamaria, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio (Sep 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". J. Biol. Chem. (United States) 278 (38): 36496–504.  
  5. ^ Guo, Qing; Xie Jun (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". J. Biol. Chem. (United States) 279 (6): 4596–603.  
  6. ^ Bruno, Tiziana; De Angelis Roberta, De Nicola Francesca, Barbato Christian, Di Padova Monica, Corbi Nicoletta, Libri Valentina, Benassi Barbara, Mattei Elisabetta, Chersi Alberto, Soddu Silvia, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio (Nov 2002). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell (United States) 2 (5): 387–99.  

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