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Aryl hydrocarbon receptor repressor

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Aryl hydrocarbon receptor repressor

aryl-hydrocarbon receptor repressor
Identifiers
Symbol AHRR
Alt. symbols AHH, AHHR
Entrez 57491
HUGO 346
OMIM 606517
RefSeq NM_020731
UniProt Q9ULI6
Other data
Locus Chr. 5 p15.33

The aryl-hydrocarbon receptor repressor also known as AHRR is a human gene.[1]

Function

Dioxins and dioxin-like compounds are teratogens that exert their effects through the aryl hydrocarbon receptor (AhR) in conjunction with the receptor's binding partner, aryl hydrocarbon receptor nuclear translocator (ARNT). The protein encoded by this gene represses signal transduction by the AhR by competing with the ARNT for binding to the arylhydrocarbon receptor.[2] Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor-kappa B.

The AhRR gene may act as a tumor suppressor.[3][4]

Tissue distribution

The expression of AhRR is high in testis, lung, ovary, spleen and pancreas in adults, whereas expression is low in all tissues in fetuses.[5]

References

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External links

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