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Bendavia

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Bendavia

Bendavia (or SS-31) is a small mitochondrially-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that scavenges mitochondrial reactive oxygen species, inhibits the mitochondrial permeability transition (MPT) pore,[1] and stabilizes cardiolipin.[2]

For elderly mice, it also reduces age-related declines in mitochondrial ATP production, coupling of oxidative phosphorylation (P/O), and cell energy state (PCr/ATP). It also is associated with more reduced glutathione redox status and lower mitochondrial H2O2 emission.[3] It does not have the same effect in younger mice, however.

It was discovered by Cornell professor Hazel Szeto, who later started Stealth Peptides to develop the drug.[4]

References

  1. ^ "Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury". Jasn.asnjournals.org. Retrieved 2015-05-09. 
  2. ^ "The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin". Jasn.asnjournals.org. 2013-07-11. Retrieved 2015-05-09. 
  3. ^ "Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice - Siegel - 2013 - Aging Cell - Wiley Online Library". Onlinelibrary.wiley.com. 2013-05-20. Retrieved 2015-05-09. 
  4. ^ "Interview with the Dean: Small Molecules Show Big Promise | Weill Cornell Newsroom | Weill Cornell Medical College". Weill.cornell.edu. 2014-04-10. Retrieved 2015-05-09. 
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