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Ccr4

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Ccr4

Chemokine (C-C motif) receptor 4
Identifiers
Symbols  ; CC-CKR-4; CD194; CKR4; CMKBR4; ChemR13; HGCN:14099; K5-5
External IDs IUPHAR: ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene.[1][2][3] CCR4 has also recently been designated CD194 (cluster of differentiation 194).

The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.[3]

References

  1. ^ Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem 270 (33): 19495–500.  
  2. ^ Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics 36 (3): 522–6.  
  3. ^ a b "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4". 
  4. ^ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42.  
  5. ^ Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8.  

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