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Cd53

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Cd53

CD53 molecule
Identifiers
Symbols  ; MOX44; TSPAN25
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.[1][2] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.[2]

See also

References

  1. ^ Korinek V, Horejsi V (Jul 1993). "Genomic structure of the human CD53 gene". Immunogenetics 38 (4): 272–279.  
  2. ^ a b "Entrez Gene: CD53 CD53 molecule". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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