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Creb3

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Creb3

CAMP responsive element binding protein 3
Identifiers
Symbols  ; LUMAN; LZIP
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.[1][2] This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.[2]

See also

Interactions

CREB3 has been shown to interact with Host cell factor C1.[3][4]

References

  1. ^ Lu R, Yang P, O'Hare P, Misra V (Sep 1997). "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor". Mol Cell Biol 17 (9): 5117–26.  
  2. ^ a b "Entrez Gene: CREB3 cAMP responsive element binding protein 3". 
  3. ^ Lu, R; Yang P; Padmakumar S; Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. (UNITED STATES) 72 (8): 6291–7.  
  4. ^ Freiman, R N; Herr W (Dec 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. (UNITED STATES) 11 (23): 3122–7.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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