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Cell-cycle nonspecific antineoplastic agents

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Title: Cell-cycle nonspecific antineoplastic agents  
Author: World Heritage Encyclopedia
Language: English
Subject: Chemotherapy, Hazardous drugs, Thiopurine, Pyrimidine analogue, Elsamitrucin
Collection: Antineoplastic Drugs
Publisher: World Heritage Encyclopedia

Cell-cycle nonspecific antineoplastic agents

Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle.[1]

Alkylating antineoplastic agent are an example.


Further reading

  • Alberts DS, Golde DW (November 1974). "DNA synthesis in multiple myeloma cells following cell cycle-nonspecific chemotherapy". Cancer Res. 34 (11): 2911–4.  
  • Ozawa S, Sugiyama Y, Mitsuhashi Y, Kobayashi T, Inaba M (1988). "Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product". Cancer Chemother. Pharmacol. 21 (3): 185–90.  
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