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Cilengitide

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Cilengitide

Template:Chembox ChEMBL
Cilengitide
Identifiers
CAS number 188968-51-6
PubChem 176873
ChemSpider 154046 YesY
KEGG D03497 YesY
MeSH Cilengitide
Jmol-3D images Image 1
Properties
Molecular formula C27H40N8O7
Molar mass 588.66 g mol−1
Density 1.417 g/mL
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels). Hence, it is under investigation for the treatment of glioblastoma by inhibiting angiogenesis.[1][2]

The European Medicines Agency has granted cilengitide orphan drug status.[3]

References


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