World Library  
Flag as Inappropriate
Email this Article

Clarke Fraser

Frank Clarke Fraser
Born (1920-03-29)29 March 1920
Norwich, Connecticut
Died December 17, 2014(2014-12-17) (aged 94)
Occupation Medical geneticist
Awards Order of Canada
William Allan Award

Frank Clarke Fraser, OC FRSC (29 March 1920 – 17 December 2014) was a Canadian medical geneticist. Spanning the fields of science and medicine, he was Canada's first medical geneticist, one of the creators of the discipline of medical genetics in North America, and laid the foundations in the field of Genetic Counselling, which has enhanced the lives of patients worldwide. Among his many accomplishments, Fraser pioneered work in the genetics of cleft palate and popularized the concept of multifactorial disease. Fraser is an iconic figure in Canadian medicine, as well as a biomedical pioneer, a fine teacher, and an outstanding scientist.[1]


  • Biography 1
  • Further reading 2
  • References 3
  • External links 4


Born in Norwich, Connecticut, he returned with his family to Canada when he was an infant. After a few years in Dublin where his father, Frank Wise Fraser was Canadian Trade Commissioner, the family moved to Jamaica where he received his primary and secondary school education at Munro College. He received a Bachelor of Science degree in 1940 from Acadia University, a Master of Science degree in 1941, a Ph.D. in 1945, and a Doctor of Medicine degree in 1950 from McGill University. During World War II, he served in the Royal Canadian Air Force but did not go overseas.

Before Fraser took the stage, genetics and medicine were two very separate fields. There was no vision for the potential of genetics in human medicine. But very soon, Fraser turned his attention from fruit flies and mice to human genetics, and became the founder of the first Canadian medical genetics department in a paediatric hospital, aptly named the F. Clarke Fraser Clinical Genetics Centre at McGill University in 1995.

  • 1950: joined McGill University as an Assistant Professor of Genetics.
  • 1955: appointed an Associate and in 1960 was made a full professor.
  • 1970-82 was the Molson Professor of Genetics in the Department of Biology.
  • 1973-82, was also a Professor of Paediatrics.
  • 1979-82, Professor in the McGill Centre for Human Genetics.
  • 1979 Founding co-director of the Medical Research Council of Canada Group in Medical Genetics, the longest lasting group in the history of the MRC.
  • 1952-82 Founder and Director of the Department of Medical Genetics at the Montreal Children's Hospital.
  • 1982-85, Professor of Clinical Genetics at Memorial University of Newfoundland.
  • 1990-93, Director of the Genetics Working Group of the Royal Commission on New Reproductive Technologies.

Fraser has served as president of the major North American societies in Genetics and Teratology and has won almost every award in his field.

He has been awarded four honorary doctorates, from Acadia University (1967), SUNY at Potsdam, Dalhousie University (2003) and McGill University (2010).

Fraser made contributions in three areas. He collected data on recurrence risks for a number of pediatric conditions, to answer the questions of the parents of affected children. He helped develop the principles of genetic counseling. He showed that cortisone, injected into pregnant mice, caused cleft palates in the offspring, and that the frequency of induced clefts varied with the genotype, thus bringing genetics into teratology. From this he developed the multifactorial threshold model that underlies many common familial conditions.

But Fraser's contributions reached far beyond the lab to the very lives of patients everywhere. His gentle, compassionate approach was much appreciated by his patients and he passed this warmth and understanding onto a succession of graduate students, physicians and genetic counsellors in both Canada and the United States. Ever contributing in a myriad of ways, Dr. Fraser’s classroom techniques were renowned among students and he coauthored several textbooks, many still used today.

Further reading

  • "Canadian Who's Who 1997 entry". University of Toronto Press. Retrieved October 13, 2006. 
  • "Prix du Québec". McGill Reporter. Retrieved October 13, 2006. 
  • "Canadian Medical Hall of Fame". Canadian Mecical Hall of Fame. Retrieved November 23, 2011. 


  1. ^ Fitterman, Lisa (2015-01-21). "Obituary: Clarke Fraser made pioneering discoveries in McGill’s ‘mouse room’".  

External links

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.