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Corrin

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Title: Corrin  
Author: World Heritage Encyclopedia
Language: English
Subject: Hosseinabad, Corrin, Vitamin B12, Conjugated system, Polycyclic aromatic compounds, Schiff base
Collection: Biomolecules, MacRocycles, Metabolism, Tetrapyrroles
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Corrin

Corrin
Identifiers
 Y
ChEBI  Y
ChemSpider  Y
Jmol-3D images Image
PubChem
Properties
C19H22N4
Molar mass 306.40478
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 Y  (: Y/N?)

Corrin is an heterocyclic compound. It is the parent macrocycle related to substituted derivative that is found in vitamin B12. Its name reflects that it is the "core" of vitamin B12 (cobalamins).[1]

Coordination chemistry

Upon deprotonation, the corrinoid ring is capable of binding cobalt. In vitamin B12, the resulting complex also features a benzimidazole-derived ligand, and the sixth site on the octahedron serves as the catalytic center.

The corrin ring resembles the porphyrins, corrins lack one of the carbon groups that link the pyrrole-like units. Thus the large ring has 19 carbons, whereas porphyrins have 20. Also, the pyrrole-like rings in corrin are fully saturated "edge-carbon" centers. Because of the high number of sp3 carbon centers, corrins are more flexible than porphyrins and are not as flat. They do not have a full conjugated character around the entire ring. Instead, the ring has a kind of "3/4" conjugation.

Corroles (octadehydrocorrins) are fully aromatic derivatives of corrins.

References

  1. ^ Nelson, D. L.; Cox, M. M. "Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000. ISBN 1-57259-153-6.
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