World Library  
Flag as Inappropriate
Email this Article

Cyanovirin-N

Article Id: WHEBN0006155552
Reproduction Date:

Title: Cyanovirin-N  
Author: World Heritage Encyclopedia
Language: English
Subject: Virucide, Proteomics, Morpheein, Abzyme, Protease inhibitor (pharmacology)
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Cyanovirin-N

Cyanovirin-N (CV-N) is a protein produced by the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (HIV).[1] The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope.[2] In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin.[3] CV-N has a complex fold composed of a duplication of a tandem repeat of two homologous motifs comprising three-stranded beta-sheet and beta-hairpins.[4]

Professor Julian Ma of St George's Hospital, South London, has a project in Kent, England to use genetically modified tobacco plants to produce the Cyanovirin and from this produce a cream which could be used to prevent HIV infection

Cyanovirin a protein with a highly complicated structure, it binds to sugars attached to HIV,it envelopes the protein and prevents it from binding to the mucosal cell surfaces in the Vagina and Rectum, this compound is also active against herpes viruses.

"development of cyanovirin has been exceedingly slow-paced. The chief of the NCI cyanovirin program, Michael Boyd, described it as "languishing." Apparently the NCI's production facilities, based on genetically manipulated cell cultures, have been diverted to other projects that the agency considers of higher priority. This is unfortunate: cyanovirin is of particular interest because of its relative safety. It is 10,000 times more toxic to HIV than it is to cells."

This protein may use the morpheein model of allosteric regulation. [5]


References

  1. ^
  2. ^
  3. ^
  4. ^
  5. ^

External links

  • BBC News Article on using Tobacco Plants to produce Cyanovirin
  • Freedom Antiviral for Freedom from STDs


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.