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Title: Ddr1  
Author: World Heritage Encyclopedia
Language: English
Subject: Fibroblast growth factor receptor 4, TEK tyrosine kinase, Kinase insert domain receptor, PDGFRB, Discoidin domain-containing receptor 2
Collection: Clusters of Differentiation
Publisher: World Heritage Encyclopedia


Discoidin domain receptor tyrosine kinase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.[1] Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the DDR2 protein.[2] In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.[1]


  1. ^ a b "Entrez Gene: DDR1 discoidin domain receptor family, member 1". 
  2. ^ Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R (March 2013). "Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.". J. Biol Chem. 288 (11): 7430–9.  

Further reading

  • Edelhoff S, Sweetser DA, Disteche CM (1995). "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C". Genomics 25 (1): 309–11.  
  • Shelling AN, Butler R, Jones T et al. (1995). "Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16". Genomics 25 (2): 584–7.  
  • Weiner TM, Liu ET, Craven RJ, Cance WG (1995). "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors". Ann. Surg. Oncol. 1 (1): 18–27.  
  • Laval S, Butler R, Shelling AN et al. (1995). "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line". Cell Growth Differ. 5 (11): 1173–83.  
  • Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". Mol. Cell. Biol. 14 (4): 2713–21.  
  • Di Marco E, Cutuli N, Guerra L et al. (1993). "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues". J. Biol. Chem. 268 (32): 24290–5.  
  • Perez JL, Shen X, Finkernagel S et al. (1994). "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene 9 (1): 211–9.  
  • Johnson JD, Edman JC, Rutter WJ (1993). "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5677–81.  
  • Perez JL, Jing SQ, Wong TW (1996). "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines". Oncogene 12 (7): 1469–77.  
  • Valent A, Meddeb M, Danglot G et al. (1996). "Assignment of the NTRK4 (trkE) gene to chromosome 6p21". Hum. Genet. 98 (1): 12–5.  
  • Playford MP, Butler RJ, Wang XC et al. (1996). "The genomic structure of discoidin receptor tyrosine kinase". Genome Res. 6 (7): 620–7.  
  • Sakuma S, Saya H, Tada M et al. (1997). "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein". FEBS Lett. 398 (2–3): 165–9.  
  • Nemoto T, Ohashi K, Akashi T et al. (1998). "Overexpression of protein tyrosine kinases in human esophageal cancer". Pathobiology 65 (4): 195–203.  
  • Tanaka K, Nagayama Y, Nakano T et al. (1998). "Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid". Endocrinology 139 (3): 852–8.  
  • Vogel W, Gish GD, Alves F, Pawson T (1998). "The discoidin domain receptor tyrosine kinases are activated by collagen". Mol. Cell 1 (1): 13–23.  
  • Shrivastava A, Radziejewski C, Campbell E et al. (1998). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Mol. Cell 1 (1): 25–34.  
  • Vogel W, Brakebusch C, Fässler R et al. (2000). "Discoidin domain receptor 1 is activated independently of beta(1) integrin". J. Biol. Chem. 275 (8): 5779–84.  
  • Foehr ED, Tatavos A, Tanabe E et al. (2000). "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors". FASEB J. 14 (7): 973–81.  
  • Weiner HL, Huang H, Zagzag D et al. (2001). "Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors". Neurosurgery 47 (6): 1400–9.  
  • Mohan RR, Mohan RR, Wilson SE (2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea". Exp. Eye Res. 72 (1): 87–92.  

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