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Deoxyadenosine

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Title: Deoxyadenosine  
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Subject: Nucleotide, Thymidine, Adenine, Dam methylase, Depurination
Collection: Nucleosides, Purines
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Deoxyadenosine

Deoxyadenosine
Skeletal formula of deoxyadenosine
Space-filling model of the deoxyadenosine molecule
Names
IUPAC name
5-(6-Aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
Other names
2'-Deoxyadenosine; α-Deoxyadenosine; dA
Identifiers
 Y
ChEBI  Y
ChEMBL  N
ChemSpider  Y
Jmol-3D images Image
MeSH
PubChem
UNII  Y
Properties
C10H13N5O3
Molar mass 251.24192
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: Y/N?)

Deoxyadenosine is a deoxyribonucleoside. It is a derivative of the nucleoside adenosine, differing from the latter by the replacement of a hydroxyl group (-OH) by hydrogen (-H) at the 2' position of its ribose sugar moiety. Deoxyadenosine is the DNA nucleoside A, which pairs with deoxythymidine (T) in double-stranded DNA. In absence of adenosine deaminase (ADA) it accumulates in T lymphocytes and kills these cells resulting in a genetic disorder known as adenosine deaminase severe combined immunodeficiency disease (ADA-SCID).[1]

See also

References

  1. ^ Griffiths, Anthony J. F.; Wessler, Susan R.; Carroll, Sean B.; Doebly, John (2012). Introduction to Genetic Analysis (10th ed.). New York: W . H. Freeman and Company.  


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