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Title: Deoxyadenosine  
Author: World Heritage Encyclopedia
Language: English
Subject: Nucleotide, Thymidine, Adenine, Dam methylase, Depurination
Collection: Nucleosides, Purines
Publisher: World Heritage Encyclopedia


Skeletal formula of deoxyadenosine
Space-filling model of the deoxyadenosine molecule
IUPAC name
Other names
2'-Deoxyadenosine; α-Deoxyadenosine; dA
ChemSpider  Y
Jmol-3D images Image
Molar mass 251.24192
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: Y/N?)

Deoxyadenosine is a deoxyribonucleoside. It is a derivative of the nucleoside adenosine, differing from the latter by the replacement of a hydroxyl group (-OH) by hydrogen (-H) at the 2' position of its ribose sugar moiety. Deoxyadenosine is the DNA nucleoside A, which pairs with deoxythymidine (T) in double-stranded DNA. In absence of adenosine deaminase (ADA) it accumulates in T lymphocytes and kills these cells resulting in a genetic disorder known as adenosine deaminase severe combined immunodeficiency disease (ADA-SCID).[1]

See also


  1. ^ Griffiths, Anthony J. F.; Wessler, Susan R.; Carroll, Sean B.; Doebly, John (2012). Introduction to Genetic Analysis (10th ed.). New York: W . H. Freeman and Company.  

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