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Dimethylaminopivalophenone

 

Dimethylaminopivalophenone

Dimethylaminopivalophenone
Systematic (IUPAC) name
3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one
Identifiers
CAS Registry Number
PubChem CID:
ChemSpider
Chemical data
Formula C13H19NO
Molecular mass 205.30 g·mol−1

Dimethylaminopivalophenone[1][2] is a a potent opioid analgesic.[3] It was initially discovered by Russian scientists in 1954 and subsequently rediscovered in the US in 1969.[4] Its LD50 in mice is 83mg/kg.[5]

See also

References

  1. ^ James H. Brewster, Ernest L. Eliel (2011). "Carbon-Carbon Alkylations with Amines and Ammonium Salts". Organic Reactions 7 (3): 99–197.  
  2. ^ Edward F. Kleinman (April 2011). "Dimethyl(methylene)ammonium Iodide". e-EROS Encyclopedia of Reagents for Organic Synthesis.  
  3. ^ Helmut Buschmann, Wolfgang Strassburger, Elmar Friderichs (24 January 2002). "Patent US 20020010178 - 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effect". Retrieved 2 October 2015. 
  4. ^ Manmohan S. Atwal, Ludwig Bauer, S. N. Dixit, J. E. Gearien, M. Magahy, R. Morris, C. Pokorny (November 1969). "Analgetics. II. Relationship between structure and activity of some beta-amino ketones.". Journal of Medicinal Chemistry 12 (6): 994–997.  
  5. ^ "2,2-dimethyl-3-(dimethylamino)-Propiophenone". ChemIDplus. Retrieved 2 October 2015. 
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