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Title: Eif4ebp1  
Author: World Heritage Encyclopedia
Language: English
Subject: Interferon, Mammalian target of rapamycin, Chordoma, Serine/arginine-rich splicing factor 1
Publisher: World Heritage Encyclopedia


Eukaryotic translation initiation factor 4E binding protein 1
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene.[1]

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.[2]


EIF4EBP1 has been shown to interact with Mammalian target of rapamycin,[3][4][5][6][7][8][9][10] EIF4E[11][12][13][14][15][16][17][18][19][20][21][22][23] and KIAA1303.[3][6][9][10][15][24][25][26]


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