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EPH receptor B2

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EPH receptor B2

EPH receptor B2
PDB rendering based on 1b4f.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.10.1
RNA expression pattern

Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.[1]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[2]

Animal studies

EphB2 is part of the NMDA signaling pathway and restoring expression rescues cognitive function in an animal model of Alzheimer's disease.[3]

A recessive EphB2 gene is responsible for the crested-feather mutation in pidgeons.[4]

Interactions

EPH receptor B2 has been shown to interact with Src,[5][6] RAS p21 protein activator 1[7] and the Abl gene.[8]

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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