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Edoxaban

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Edoxaban

Edoxaban (INN, codenamed DU-176b, trade name Lixiana) is an anticoagulant drug which acts as a direct factor Xa inhibitor. It is being developed by Daiichi Sankyo. It was approved in July 2011 in Japan for prevention of venous thromboembolisms (VTE) following lower-limb orthopedic surgery.[1]

Preclinical research

In animal studies, edoxaban is potent, selective for factor Xa and has good oral bioavailability.[2]

Clinical trials

Several Phase II clinical trials have been conducted, for example for thromboprophylaxis after total hip replacement[3] (phase III early results compare well to enoxaparin[4]), and for stroke prevention in patients with atrial fibrillation[5] (phase III has completed enrollment[4]).

A large phase III trial showed that edoxaban was non inferior to warfarin in preventing recurrent venous thromboembolic events with fewer episodes of major bleeding.[6] This paper follows similar recent major trials showing similar results for the other new factor Xa inhibitors, rivaroxaban and apixaban.[5]

References


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