World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0033771146
Reproduction Date:

Title: Epristeride  
Author: World Heritage Encyclopedia
Language: English
Subject: Galeterone, Abiraterone acetate, Cyproterone acetate, Testosterone, Anabolic steroid
Collection: 5-Alpha-Reductase Inhibitors, Anti-Acne Preparations, Carboxylic Acids, Dienes
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
17-(tert-butylcarbamoyl)androsta-3,5-diene-3-carboxylic acid
Clinical data
Legal status
  • Non-regulated
Routes Oral
Pharmacokinetic data
Bioavailability 93%[1]
Half-life 26 hours[1]
CAS number
ATC code None
Chemical data
Formula C25H37NO3 
Mol. mass 399.566 g/mol

Epristeride (SKF-105,657, ONO-9302) is a selective, transition state, non-competitive inhibitor of the type II isoform of the enzyme 5α-reductase,[2][3] similarly to finasteride and turosteride. It was under development for the treatment of benign prostatic hyperplasia and acne vulgaris by SmithKline Beecham (now GlaxoSmithKline), and reached phase III clinical trials in the United States, United Kingdom, and Japan,[2] but ultimately was never marketed.

See also


  1. ^ a b Benincosa LJ, Audet PR, Lundberg D, Zariffa N, Jorkasky DK (April 1996). "Pharmacokinetics and absolute bioavailability of epristeride in healthy male subjects". Biopharmaceutics & Drug Disposition 17 (3): 249–58.  
  2. ^ a b Hedge SS (May 1998). "Epristeride SmithKline Beecham". IDrugs : the Investigational Drugs Journal 1 (1): 152–7.  
  3. ^ Berthaut I, Mestayer C, Portois MC, Cussenot O, Mowszowicz I (August 1997). "Pharmacological and molecular evidence for the expression of the two steroid 5 alpha-reductase isozymes in normal and hyperplastic human prostatic cells in culture". The Prostate 32 (3): 155–63.  

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.