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Eternal youth

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Title: Eternal youth  
Author: World Heritage Encyclopedia
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Subject: Ageless, Isaac and Miria, Ageing, Paranormal, Longevity
Collection: Ageing, Death, Fictional Superhuman Features or Abilities, Life Extension, Mythological Powers, Youth
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Eternal youth

Youth and Time, John William Godward, 1901

Eternal youth is the concept of human physical immortality free of aging. The youth referred to is usually meant to be in contrast to the depredations of aging, rather than a specific age of the human lifespan. Achieving eternal youth so far remains beyond the capabilities of scientific technology. However, much research is being conducted in the sciences of genetics which may allow manipulation of the aging process in the future. Eternal youth is common in mythology, and is a popular theme in fiction.

Contents

  • Religion and mythology 1
  • Telomeres 2
  • Therapy 3
  • Philanthropy 4
  • See also 5
  • References 6

Religion and mythology

Eternal youth is a characteristic of the inhabitants of Paradise in Abrahamic religions.

The Hindus believe that the Vedic and the post-Vedic rishis have attained immortality, which implies the ability to change one's body's age or even shape at will. These are some of the siddhas in Yoga. Markandeya is said to always stay at the age of 16.

The difference between eternal life and the more specific eternal youth is a recurrent theme in Tithonus. A similar theme is found in Ovid regarding the Cumaean Sibyl.

In Norse mythology, Iðunn is described as providing the gods apples that grant them eternal youthfulness in the 13th century Prose Edda.

Telomeres

An individual's

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  2. ^ Gomes NM, Ryder OA, Houck ML, Charter SJ, Walker W, Forsyth NR, Austad SN, Venditti C, Pagel M, Shay JW, Wright WE (2011). Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell 10(5):761-768. doi: 10.1111/j.1474-9726.2011.00718.x. PMID 21518243
  3. ^ Cherif H, Tarry JL, Ozanne SE, Hales CN (2003). Ageing and telomeres: a study into organ- and gender-specific telomere shortening. Nucleic Acids Res 31(5):1576-1583. PMID 12595567
  4. ^ Renault V, Thornell LE, Eriksson PO, Butler-Browne G, Mouly V (2003). Regenerative potential of human skeletal muscle during aging. Aging Cell 1(2):132-139. PMID 12882343
  5. ^ Jeyapalan JC, Ferreira M, Sedivy JM, Herbig U (2007) Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 128(1):36-44. PMID 17116315
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References

See also

The 'loss of youth' or ageing process is responsible for increasing the risk of individuals to many diseases including Cancer, Parkinsons, alzheimers, and others. As a result in recent years many high net worth individuals such as Peter Thiel,[11] Aubrey de Grey,[12] Larry Ellison, Sergey Brin, Dmitry Itskov, Paul Glenn,[13] and Mark Zuckerberg [14] have donated large amounts of their money towards initiatives towards scientific research into the ageing process itself or therapies to slow or reverse the ageing process. This would allow humans to extend their youth or maintain youth indefinitely.

Philanthropy

The idea that the human body can be repaired in old age to a more youthful state has gathered significant commercial interest over the past few years, including by companies such as Human Longevity Inc, Google Calico and Elysium Health (supported by seven Nobel Prize winning scientists). In addition to these larger companies, many startups are currently developing therapeutics to tackle the 'ageing problem' using therapy.[8][9] In 2015 a new class of drugs senolytics was announced (currently in pre-clinical development) designed specifically to combat the underlying biological causes of frailty.[10]

Therapy

Studies have shown that 90 percent of cancer cells contain large amounts of an enzyme called telomerase.[6] Telomerase is an enzyme that replenishes the worn away telomeres by adding bases to the ends and thus renewing the telomere. A cancer cell has in essence turned on the telomerase gene, and this allows them to have an unlimited amount of divisions without the telomeres wearing away. Other kinds of cells that can surpass the Hayflick limit are stem cells, hair follicles, and germ cells.[7] This is because they contain raised amounts of telomerase.

However a study of the comparative biology of mammalian telomeres indicated that telomere length correlates inversely, rather than directly, with lifespan, and concluded that the contribution of telomere length to lifespan remains controversial.[2] Also, telomere shortening does not occur with age in a some postmitotic tissues, such as in the rat brain.[3] In humans, skeletal muscle telomere lengths remain stable from ages 23–74.[4] In baboon skeletal muscle, that consists of fully differentiated post-mitotic cells, less than 3% of myonuclei contain damaged telomeres and this percentage does not increase with age.[5] Thus telomere shortening does not appear to be a major factor in the aging of the differentiated cells of brain or skeletal muscle.

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