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Fhl2

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Fhl2

Four and a half LIM domains 2

PDB rendering based on 1x4k.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; AAG11; DRAL; FHL-2; SLIM-3; SLIM3
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Four and a half LIM domains protein 2 is a protein that in humans is encoded by the FHL2 gene.[1] LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM][2]

Interactions

FHL2 has been shown to interact with Beta-catenin,[3] Titin,[4] Zinc finger and BTB domain-containing protein 16,[5] Integrin, beta 6,[6] Androgen receptor,[7] ITGA7,[8] CREB1,[9] MAPK1,[10] CD49c,[6] ZNF638,[11] BRCA1,[12][13] FHL3,[9][14] IGFBP5,[15] TRAF6,[16] EIF6,[6] CD18,[6] CD29[6] and PSEN2.[17]

References

  1. ^ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem. Biophys. Res. Commun. 225 (2): 632–8.  
  2. ^ "Entrez Gene: FHL2 four and a half LIM domains 2". 
  3. ^ Wei, Yu; Renard Claire-Angélique; Labalette Charlotte; Wu Yuanfei; Lévy Laurence; Neuveut Christine; Prieur Xavier; Flajolet Marc; Prigent Sylvie; Buendia Marie-Annick (February 2003). "Identification of the LIM protein FHL2 as a coactivator of beta-catenin". J. Biol. Chem. (United States) 278 (7): 5188–94.  
  4. ^ Lange, Stephan; Auerbach Daniel; McLoughlin Patricia; Perriard Evelyne; Schäfer Beat W; Perriard Jean-Claude; Ehler Elisabeth (December 2002). "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2". J. Cell. Sci. (England) 115 (Pt 24): 4925–36.  
  5. ^ McLoughlin, Patricia; Ehler Elisabeth; Carlile Graeme; Licht Jonathan D; Schäfer Beat W (October 2002). "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein". J. Biol. Chem. (United States) 277 (40): 37045–53.  
  6. ^ a b c d e Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78.  
  7. ^ Müller, J M; Isele U; Metzger E; Rempel A; Moser M; Pscherer A; Breyer T; Holubarsch C; Buettner R; Schüle R (February 2000). "FHL2, a novel tissue-specific coactivator of the androgen receptor". EMBO J. (ENGLAND) 19 (3): 359–69.  
  8. ^ Samson, Thomas; Smyth Neil; Janetzky Stefanie; Wendler Olaf; Müller Judith M; Schüle Roland; von der Mark Helga; von der Mark Klaus; Wixler Viktor (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. (United States) 279 (27): 28641–52.  
  9. ^ a b Fimia, G M; De Cesare D, Sassone-Corsi P (November 2000). "A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613–22.  
  10. ^ Purcell, Nicole H; Darwis Dina; Bueno Orlando F; Müller Judith M; Schüle Roland; Molkentin Jeffery D (February 2004). "Extracellular Signal-Regulated Kinase 2 Interacts with and Is Negatively Regulated by the LIM-Only Protein FHL2 in Cardiomyocytes". Mol. Cell. Biol. (United States) 24 (3): 1081–95.  
  11. ^ Ng, Enders Kai On; Chan Kwok Keung; Wong Chi Hang; Tsui Stephen Kwok Wing; Ngai Sai Ming; Lee Simon Ming Yuen; Kotaka Masayo; Lee Cheuk Yu; Waye Mary Miu Yee; Fung Kwok Pui (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. (United States) 84 (3): 556–66.  
  12. ^ Yan, Jinghua; Zhu Jianhua; Zhong Hongjun; Lu Qiujun; Huang Cuifen; Ye Qinong (October 2003). "BRCA1 interacts with FHL2 and enhances FHL2 transactivation function". FEBS Lett. (Netherlands) 553 (1–2): 183–9.  
  13. ^ Yan, Jing-Hua; Ye Qi-Nong; Zhu Jian-Hua; Zhong Hong-Jun; Zheng Hui-Yong; Huang Cui-Fen (December 2003). "[Isolation and characterization of a BRCA1-interacting protein]". Yi Chuan Xue Bao (China) 30 (12): 1161–6.  
  14. ^ Li, H Y; Ng E K; Lee S M; Kotaka M; Tsui S K; Lee C Y; Fung K P; Waye M M (2001). "Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. (United States) 80 (3): 293–303.  
  15. ^ Amaar, Yousef G; Thompson Garrett R; Linkhart Thomas A; Chen Shin-Tai; Baylink David J; Mohan Subburaman (April 2002). "Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)". J. Biol. Chem. (United States) 277 (14): 12053–60.  
  16. ^ Bai, Shuting; Zha Jikun; Zhao Haibo; Ross F Patrick; Teitelbaum Steven L (November 2008). "Tumor Necrosis Factor Receptor-associated Factor 6 Is an Intranuclear Transcriptional Coactivator in Osteoclasts". J. Biol. Chem. (United States) 283 (45): 30861–7.  
  17. ^ Tanahashi, H; Tabira T (September 2000). "Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein". Hum. Mol. Genet. (ENGLAND) 9 (15): 2281–9.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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