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Fadrozole

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Fadrozole

Fadrozole
Systematic (IUPAC) name
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Clinical data
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  N
UNII  N
KEGG  YesY
ChEMBL  N
Chemical data
Formula C14H13N3 
Mol. mass 223.27 g/mol
 N   

Fadrozole (INN, marketed as Afema by Novartis) is an aromatase inhibitor[1] that has been introduced in Japan for the treatment of breast cancer.

It is selective.[2]

References

  1. ^ Raats JI, Falkson G, Falkson HC (January 1992). "A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer". J. Clin. Oncol. 10 (1): 111–6.  
  2. ^ Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A (February 1991). "Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease". J. Med. Chem. 34 (2): 725–36.  

See also



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