World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0001269331
Reproduction Date:

Title: Felodipine  
Author: World Heritage Encyclopedia
Language: English
Subject: AstraZeneca, Nicardipine, Grapefruit–drug interactions, Calcium channel blocker, ATC code C08
Collection: Calcium Channel Blockers, Carboxylate Esters, Chloroarenes, Dihydropyridines, Organochlorides
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(RS)-3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
Trade names Plendil
  • US: C (Risk not ruled out)
Legal status
  • (Prescription only)
Routes of
Pharmacokinetic data
Bioavailability 15%[1]
Metabolism Hepatic
Onset of action 2.5–5 hours
Biological half-life 25 hours[2]
Excretion Renal
CAS Registry Number  Y
ATC code C08
PubChem CID:
DrugBank  Y
ChemSpider  Y
Chemical data
Formula C18H19Cl2NO4
Molecular mass 384.259 g/mol

Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). It is marketed under the brand name Plendil by AstraZeneca and Renedil by Sanofi-Aventis. The formulation patent for the substance expired in 2007.

AstraZeneca dropped Plendil from its support and AZ&Me free Rx access program in October 2008.


Studies dating back to 1989 have suggested that felodipine in combination with grapefruit juice can cause toxic effects. Oral administration of felodipine is first metabolized in the gastrointestinal tract and liver by the enzyme CYP3A4. Grapefruit juice contains bergamottin which is found to have an inhibiting effect over this enzyme and as a result the bioavailability of the drug increases, raising the risk for abnormal side effects.[3]

Contraindications and cautions

Contraindicated with allergy to felodipine or other calcium channel blockers, sick sinus syndrome, AV heart block (second and third degree), lactation. Use cautiously with pregnancy, impaired hepatic function.


  1. ^ AstraZeneca MI Department, 16 April 2010.
  2. ^,+Plendil+5mg+and+Plendil+10mg/
  3. ^ Jawad Kiani, Sardar Z Imam (October 30, 2007). "Medicinal importance of grapefruit juice and its interaction with various drugs". Nutr J. 6 (33): 33.  .
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.