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Title: Fibrosis  
Author: World Heritage Encyclopedia
Language: English
Subject: Alcoholic liver disease, Arthrofibrosis, Connective tissue, Scar, Myelophthisic anemia
Collection: Medical Terminology, Symptoms and Signs
Publisher: World Heritage Encyclopedia


Micrograph of a heart showing fibrosis (yellow - left of image) and amyloid deposition (brown - right of image). Movat's stain.
Classification and external resources
Specialty Pathology
MeSH D005355

Fibrosis is the formation of excess fibrous

  • International Scar Meeting in Tokyo 2010 International Scar Meeting

External links

  1. ^ Glossary of dermatopathological terms. DermNet NZ
  2. ^ Trojanowska, Maria (15 June 2012). "Mediators of Fibrosis". The Open Rheumatology Journal 6 (1): 70–71.  






Micrograph showing cirrhosis of the liver. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue. The red areas are the nodular liver tissue

Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include:

Examples of fibrosis

Fibrosis is similar to the process of scarring, in that both involve stimulated cells laying down connective tissue, including collagen and glycosaminoglycans. Immune cells called macrophages, as well as any damaged tissue between surfaces called interstitium, release TGF beta. There are numerous reasons for this, including inflammation of the nearby tissue, or a generalised inflammatory state, with increased circulating mediators. TGF beta stimulates the proliferation and activation of fibroblasts, which deposit connective tissue.[2]



  • Physiology 1
  • Examples of fibrosis 2
  • References 3
  • External links 4


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