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Title: Fursultiamine  
Author: World Heritage Encyclopedia
Language: English
Subject: Thiamine, Beta-Tocopherol, Menadiol, 22-Dihydroergocalciferol, Alpha-Tocotrienol
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
Routes Oral
CAS number
ATC code None
Chemical data
Formula C17H26N4O3S2 
Mol. mass 398.54 g/mol

Fursultiamine (INN; Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor), also known as thiamine tetrahydrofurfuryl disulfide (TTFD), is a disulfide derivative of thiamine, or an allithiamine.[1] It was synthesized in Japan in the 1960s for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B1 deficiency (i.e., beriberi),[1][2] and was subsequently commercialized not only in Japan but also in Spain, Austria, Germany, and the United States.[3] As a vitamin, it is available over-the-counter as well.[4]

In addition to its clinical indication of avitaminosis, fursultiamine has been studied in clinical trials for Alzheimer's disease and autistic spectrum disorders with positive but modest benefits.[5][6] It has also been investigated in improving energy metabolism during exercise and reducing exercise-induced fatigue with conflicting results.[4][7][8][9]

Available Brands: Privitamix softgel (India)

See also


  1. ^ a b Lonsdale D (September 2004). "Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent". Medical Science Monitor : International Medical Journal of Experimental and Clinical Research 10 (9): RA199–203.  
  2. ^ Miura S (July 1965). "[The uptake and the distribution of thiamine propyl disulfide-35S by the rabbit's eye tissue]". Nippon Ganka Gakkai Zasshi (in Japanese) 69 (7): 792–807, discussion 807–8.  
  3. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932.  
  4. ^ a b Nozaki S, Mizuma H, Tanaka M, et al. (December 2009). "Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats". Nutrition Research (New York, N.Y.) 29 (12): 867–72.  
  5. ^ Mimori Y, Katsuoka H, Nakamura S (March 1996). "Thiamine therapy in Alzheimer's disease". Metabolic Brain Disease 11 (1): 89–94.  
  6. ^ Lonsdale D, Shamberger RJ, Audhya T (August 2002). "Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study". Neuro Endocrinology Letters 23 (4): 303–8.  
  7. ^ Suzuki M, Itokawa Y (March 1996). "Effects of thiamine supplementation on exercise-induced fatigue". Metabolic Brain Disease 11 (1): 95–106.  
  8. ^ Webster MJ, Scheett TP, Doyle MR, Branz M (1997). "The effect of a thiamin derivative on exercise performance". European Journal of Applied Physiology and Occupational Physiology 75 (6): 520–4.  
  9. ^ Masuda H, Matsumae H, Masuda T, Hatta H (2010). "A thiamin derivative inhibits oxidation of exogenous glucose at rest, but not during exercise". Journal of Nutritional Science and Vitaminology 56 (1): 9–12.  

Further reading

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