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Title: Gdf5  
Author: World Heritage Encyclopedia
Language: English
Subject: Brachydactyly, TGF beta signaling pathway, Transforming growth factor beta superfamily, Growth differentiation factor, BMPR1B
Publisher: World Heritage Encyclopedia


Growth differentiation factor 5
PDB rendering based on 1waq.
Available structures
PDB Ortholog search: RCSB
GDF5 Gene
RNA expression pattern

Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene.[1][2][3]

The protein encoded by this gene is closely related to the bone morphogenetic protein (BMP) family and is a member of the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.[3]

Growth differentiation factor 5 (GDF5) is a protein belonging to the transforming growth factor beta superfamily that is expressed in the developing central nervous system,[4] and has a role in skeletal and joint development.[5][6][7] It also increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.[8]


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