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Hey1

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Hey1

Hes-related family bHLH transcription factor with YRPW motif 1

PDB rendering based on 2db7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; BHLHb31; CHF2; HERP2; HESR1; HRT-1; OAF1; hHRT1
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.[1][2][3] This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.[3]

References

  1. ^ Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech Dev 85 (1–2): 173–7.  
  2. ^ Kokubo H, Lun Y, Johnson RL (Aug 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochem Biophys Res Commun 260 (2): 459–65.  
  3. ^ a b "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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