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High-altitude adaptation in humans

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Title: High-altitude adaptation in humans  
Author: World Heritage Encyclopedia
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Subject: Effects of high altitude on humans, EPAS1, Respiratory physiology, Anthropology, Evolutionary biology
Collection: Anthropology, Evolutionary Biology, Human Evolution, Mountaineering and Health, Respiratory Physiology
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High-altitude adaptation in humans

High-altitude adaptation in humans is an instance of evolutionary modification in human populations in Tibet, the Andes and Ethiopia, who have acquired the ability to survive at extremely high altitudes. The phrase is used to signify irreversible, long-term physiological responses to high-altitude environments, associated with heritable behavioural and genetic changes. While the rest of human population would suffer serious health consequences, these native inhabitants thrive well in the highest parts of the world. These people have undergone extensive physiological and genetic changes, particularly in the regulatory systems of respiration and circulation, when compared to the general lowland population.[1][2] This special adaptation is now recognised as a clear example of natural selection in action.[3] In fact, the adaptation account of the Tibetans has become the fastest case of human evolution in the scientific record, as it is estimated to have occurred in less than 3,000 years.[4][5][6]


  • Origin and basis 1
  • Physiological basis 2
    • Tibetans 2.1
    • Andeans 2.2
    • Ethiopians 2.3
  • Genetic basis 3
    • Tibetans 3.1
    • Andeans 3.2
    • Ethiopians 3.3
  • See also 4
  • References 5
  • External links 6

Origin and basis

Himalayas, on the southern rim of the Tibetan Plateau

Human species are naturally adapted to lowland environment where oxygen is generally abundant.[7] When people from the general lowlands go to altitudes above 2,500 metres (8,200 ft), they experience mountain sickness, which is a type of hypoxia, a clinical syndrome of severe lack of oxygen. Complications include fatigue, dizziness, breathlessness, headaches, insomnia, malaise, nausea, vomiting, body pain, loss of appetite, ear-ringing, blistering and purpling of the hands and feet, and dilated veins.[8][9][10] The sickness is compounded by related symptoms such as cerebral oedema (swelling of brain) and pulmonary oedema (fluid accumulation in lungs).[11][12] For several days, they breathe excessively and burn extra energy even when the body is relaxed. The heart rate then gradually decreases. Hypoxia, in fact, is one of the principal causes of death among mountaineers.[13][14] In women, pregnancy can be severely affected, such as development of high blood pressure, called preeclampsia, which causes premature labour, low birth weight of babies, and often complicated with profuse bleeding, seizures, and death of the mother.[1][15]

More than 140 million people worldwide are estimated to live at an elevation higher than 2,500 metres (8,200 ft) above sea level, of which 13 million are in Ethiopia, 1.7 million in Tibet (total of 78 million in Asia), 35 million in the South American Andes, and 0.3 million in Colorado Rocky Mountains.[16] Certain natives of Tibet, Ethiopia, and the Andes have been living at these high altitudes for generations and are protected from hypoxia as a consequence of genetic adaptation.[17][8] It is estimated that at 4,000 metres (13,000 ft), every lungful of air only has 60% of the oxygen molecules that people at sea level have.[16] At elevations above 7,600 metres (24,900 ft), lack of oxygen becomes seriously lethal. That is, these highlanders are constantly exposed to an intolerably low oxygen environment, yet they live without any debilitating problems in these adverse environments.[18] Basically, the shared adaptation is the ability to maintain relatively low levels of haemoglobin, which is the chemical complex for transporting oxygen in the blood.[7] One of the best documented effects of high altitude is a progressive reduction in birth weight. It has been known that women of long-resident high-altitude population are not affected. These women are known to give birth to heavier-weight infants than women of lowland inhabitants. This is particularly true among Tibetan babies, whose average birth weight is 294-650 (~470) g heavier than the surrounding Chinese population; and their blood-oxygen level is considerably higher.[19]

The first scientific investigations of high-altitude adaptation was done by A. Roberto Frisancho of the University of Michigan in the late 1960s among the Quechua people of Peru.[20][21] However, the best scientific studies were started among the Tibetans in the early 1980s by an anthropologist Cynthia Beall at the Case Western Reserve University.[22]

Physiological basis


A Sherpa family

Scientists started to notice the extraordinary physical performance of Tibetans since the beginning of Himalayan climbing era in the early 20th century. The hypothesis of a possible evolutionary genetic adaptation makes sense.[23] The Tibetan plateau has an average elevation of 4,000 metres (13,000 ft) above sea level, and covering more than 2.5 million km, it is the highest and largest plateau in the world. In 1990, it was estimated that 4,594,188 Tibetans live on the plateau, with 53% living at an altitude over 3,500 metres (11,500 ft). Fairly large numbers (about 600,000) live at an altitude exceeding 4,500 metres (14,800 ft) in the Chantong-Qingnan area.[24] Where the Tibetan highlanders live, the oxygen level is only about 60% of that at sea level. The Tibetans, who have been living in this region for 3,000 years, do not exhibit the elevated haemoglobin concentrations to cope up with oxygen deficiency as observed in other populations who have moved temporarily or permanently at high altitudes. Instead, the Tibetans inhale more air with each breath and breathe more rapidly than either sea-level populations or Andeans. Tibetans have better oxygenation at birth, enlarged lung volumes throughout life, and a higher capacity for exercise. They show a sustained increase in cerebral blood flow, lower haemoglobin concentration, and less susceptibility to chronic mountain sickness than other populations, obviously due their longer history of high-altitude habitation.[25][26] General people can develop short-term tolerance with careful physical preparation and systematic monitoring of movements, but the biological changes are quite temporary and reversible when they return to lowlands.[27] Moreover, unlike lowland people who only experience increased breathing for a few days after entering high altitudes, Tibetans retain this rapid breathing and elevated lung-capacity throughout their lifetime.[28] This enables them to inhale larger amounts of air per unit of time to compensate for low oxygen levels. In addition, they have high levels (mostly double) of nitric oxide in their blood, when compared to lowlanders, and this probably helps their blood vessels dilate for enhanced blood circulation.[29] Further, their hemoglobin level is not significantly different (average 15.6 g/dl in males and 14.2 g/dl in females),[30] from normal human levels, in contrast to people from the Andean highlands whose hemoglobin levels are higher than normal human levels. This implies distinct mechanisms of adaptation to low oxygen supply occurring in the two distinct populations. In this way they are able to evade both the effects of hypoxia and mountain sickness throughout life. Even when they climbed the highest summits (like the Mt. Everest), they showed regular oxygen uptake, greater ventilation, more brisk hypoxic ventilatory responses, larger lung volumes, greater diffusing capacities, constant body weight and a better quality of sleep, compared to other people from the lowland.[31] Recent research indicates that altitudinal adaptation in Tibetan people is associated with a version of the EPAS1 gene acquired from archaic hominins (Denisovans).[32]


In contrast to the Tibetans, the Andean highlanders, who have been living at high-altitudes for no more than 11,000 years, do not show unique haemoglobin level. Their haemoglobin concentration is higher compared to those of lowlander population, which also happens to normal people moving to high altitude. When they spend some weeks in the lowland their heamoglobin drops to average of other people. This shows only temporary and reversible acclimatisation. However, in contrast to lowland people, they do have increased oxygen level in their haemoglobin, that is, more oxygen per blood volume than other people. This confers an ability to carry more oxygen in each red blood cell, making a more effective transport of oxygen in their body, while their breathing is essentially at the same rate.[28] This enables them to overcome hypoxia and normally reproduce without risk of death for the mother or baby. The Andean highlanders are known from the 16th-century missionaries that their reproduction had always been normal, without any effect in the giving birth or the risk for early pregnancy loss, which are common to hypoxic stress.[33] They have developmentally acquired enlarged residual lung volume and its associated increase in alveolar area, which are supplemented with increased tissue thickness and moderate increase in red blood cells. Though the physical growth in body size is delayed, growth in lung volumes is accelerated.[34] An incomplete adaptation such as elevated haemoglobin levels still leaves them at risk for mountain sickness with old age.

Quechua woman with llamas

Among the Quechua people of the Altiplano, there is a significant variation in NOS3 (the gene encoding endothelial nitric oxide synthase, eNOS), which is associated with higher levels of nitric oxide in high altitude.[35] Nuñoa children of Quechua ancestry exhibit higher blood-oxygen content (91.3) and lower heart rate (84.8) than their counterpart school children of different ethnicity, who have an average of 89.9 blood-oxygen and 88-91 heart rate.[36] High-altitude born and bred females of Quechua origins have comparatively enlarged lung volume for increased respiration.[37]

Aymara ceremony

Blood profile comparisons show that among the Andeans, Aymaran highlanders are better adapted to highlands than the Quechuas.[38][39] Among the Bolivian Aymara people, the resting ventilation and hypoxic ventilatory response were quite low (roughly 1.5 times lower), in contrast to those of the Tibetans. The intrapopulation genetic variation was relatively less among the Aymara people.[40][41] Moreover, unlike the Tibetans, the blood haemoglobin level is quite normal among Aymarans, with an average of 19.2 g/dl for males and 17.8 g/dl for females.[30] Among the different native highlander populations, the underlying physiological responses to adaptation are quite different. For example, among four quantitative features, such as are resting ventilation, hypoxic ventilatory response, oxygen saturation, and haemoglobin concentration, the levels of variations are significantly different between the Tibetans and the Aymaras.[42] The Andeans, in general are the most poorly adapted, as particularly shown by their frequent mountain sickness and loss of adaptative characters when they move to lowlands.[43]


The peoples of the Ethiopian highlands also live at extremely high altitudes, around 3,000 metres (9,800 ft) to 3,500 metres (11,500 ft). Highland Ethiopians exhibit elevated haemoglobin levels, like Andeans and lowlander peoples at high altitudes, but do not exhibit the Andean’s increased in oxygen-content of haemoglobin.[44] Among healthy individuals, the average haemoglobin concentrations are 15.9 and 15.0 g/dl for males and females respectively (which is lower than normal, almost similar to the Tibetans), and an average oxygen content of haemoglobin is 95.3% (which is higher than average, like the Andeans).[45] Additionally, Ethiopian highlanders do not exhibit any significant change in blood circulation of the brain, which has been observed among the Peruvian highlanders (and attributed to their frequent altitude-related illnesses).[46] Yet, similar to the Andeans and Tibetans, the Ethiopian highlanders are immune to the extreme dangers posed by high-altitude environment, and the pattern of adaptation definite unique from the other highland people.[16]

Genetic basis

The underlying molecular evolution of high-altitude adaptation has been explored and understood fairly recently.[18] Depending on the geographical and environmental pressures, high-altitude adaptation involves different genetic patterns. At the turn of the 21st century, it was reported that the genetic make-up of the respiratory components of the Tibetan and the Ethiopian populations are significantly different.[42]


Substantial evidence in Tibetan highlanders suggests that variation in haemoglobin and blood-oxygen levels are adaptive as Darwinian fitness. It has been documented that Tibetan women with a high likelihood of possessing one to two alleles for high blood-oxygen content (which is odd for normal women) had more surviving children; the higher the oxygen capacity, the lower the infant mortality.[47] In 2010, for the first time, the genes responsible for the unique adaptive traits were identified following genome sequences of 50 Tibetans and 40 Han Chinese from Beijing. Initially, the strongest signal of natural selection detected was a transcription factor involved in response to hypoxia, called endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1). It was found that one single-nucleotide polymorphism (SNP) at EPAS1 shows a 78% frequency difference between Tibetan and mainland Chinese samples, representing the fastest genetic change observed in any human gene to date. Hence, Tibetan adaptation to high altitude becomes the fastest process of phenotypically observable evolution in humans,[48] which is estimated to occur in less than 3,000 years ago, when the Tibetans split up from the mainland Chinese population.[6] Mutations in EPAS1, at higher frequency in Tibetans than their Han neighbours, correlate with decreased haemoglobin concentrations among the Tibetans, which is the hallmark of their adaptation to hypoxia. Simultaneously, two genes, egl nine homolog 1 (EGLN1) (which inhibits haemoglobin production under high oxygen concentration) and peroxisome proliferator-activated receptor alpha (PPARA), were also identified to be positively selected in relation to decreased haemoglobin nature in the Tibetans.[49] Similarly, the Sherpas, known for their Himalayan explorations, exhibit similar patterns in the EPAS1 gene, which further fortifies that the gene is under selection for adaptation to the high-altitude life of Tibetans.[50] EPAS1 and EGLN1 are definitely the major genes for unique adaptive traits when compared with those of the Chinese and Japanese.[51] Comparative genome analysis in 2014 revealed that the Tibetans inherited an equal mixture of genomes from the Nepalese-Sherpas and Hans, and they acquired the adaptive genes from the sherpa-lineage. Further, the population split was estimated to occur around 20,000 to 40,000 years ago, a range of which support archaeological, mitochondria DNA and Y chromosome evidence for an initial colonisation of the Tibetan plateau around 30,000 years ago.[52] The genes (EPAS1, EGLN1, and PPARA) function in concert with another gene named hypoxia inducible factors (HIF), which in turn is a principal regulator of red blood cell production (erythropoiesis) in response to oxygen metabolism.[53][54][55] The genes are associated not only with decreased haemoglobin levels, but also in regulating energy metabolism. EPAS1 is significantly associated with increased lactate concentration (the product of anaerobic glycolysis), and PPARA is correlated with decrease in the activity of fatty acid oxidation.[56] EGLN1 codes for an enzyme, prolyl hydroxylase 2 (PHD2), involved in erythropoiesis. Among the Tibetans, mutation in EGLN1 (specifically at position 12, where cytosine is replaced with guanine; and at 380, where G is replaced with C) results in mutant PHD2 (aspartic acid at position 4 becomes glutamine, and cysteine at 127 becomes serine) and this mutation inhibits erythropoiesis. The mutation is estimated to occur about 8,000 years ago.[57] Further, the Tibetans are enriched for genes in the disease class of human reproduction (such as genes from the DAZ, BPY2, CDY, and HLA-DQ and HLA-DR gene clusters) and biological process categories of response to DNA damage stimulus and DNA repair (such as RAD51, RAD52, and MRE11A), which are related to the adaptive traits of high infant birth weight and darker skin tone and are most likely due to recent local adaptation.[58]


The patterns of genetic adaptation among the Andeans are largely distinct from those of the Tibetan, with both populations showing evidence of positive natural selection in different genes or gene regions. However, EGLN1 appears to be the principal signature of evolution, as it shows evidence of positive selection in both Tibetans and Andeans. Even then, the pattern of variation for this gene differs between the two populations.[3] Among the Andeans, there are no significant associations between EPAS1 or EGLN1 SNP genotypes and haemoglobin concentration, which has been the characteristic of the Tibetans.[59] The whole genome sequences of 20 Andeans (half of them having chronic mountain sickness) revealed that two genes, SENP1 (an erythropoiesis regulator) and ANP32D (an oncogene) play vital roles in their weak adaptation to hypoxia.[60]


The adaptive mechanism of Ethiopian highlanders is quite different. This is probably because their migration to the highland was relatively earlier; for example, the Amhara have inhabited altitudes above 2,500 metres (8,200 ft) for at least 5,000 years and altitudes around 2,000 metres (6,600 ft) to 2,400 metres (7,900 ft) for more than 70,000 years.[61] Genomic analysis of two ethnic groups, Amhara and Oromo, revealed that gene variations associated with haemoglobin difference among Tibetans or other variants at the same gene location do not influence the adaptation in Ethiopians.[62] Identification of specific genes further reveals that several candidate genes are involved in Ethiopians, including CBARA1, VAV3, ARNT2 and THRB. Two of these genes (THRB and ARNT2) are known to play a role in the HIF-1 pathway, a pathway implicated in previous work reported in Tibetan and Andean studies. This supports the concept that adaptation to high altitude arose independently among different highlanders as a result of convergent evolution.[63]

See also


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External links

  • Different Genes Result In Shared Adaptation To High Altitudes
  • High-Altitude-Hypoxia: Many solutions to one problem
  • Adapting to High Altitude
  • High Altitude and Cold: Adaptation to the extremes
  • Tibetans adapted to high altitude in less than 3,000 years
  • ScienceDaily: Researchers Solve Questions About Ethiopians' High-Altitude Adaptations
  • MIT Technological Reviews: Genetic Adaptations to High Altitude
  • Altitude Illness
  • Futurity: How to thrive in thin air: It’s in the genes
  • Understanding adaptation to high altitude in the Andean region
  • BBC: Altitude tolerant
  • Understanding Evolution: The mysteries of Tibet
  • Scientific resources at the Center for Research on Tibet
  • Evolutionary Adaptations in High Altitude Tibet
  • Human Life, Aging, and Disease in High-Altitude Environments: Physio-Medical, Ecological and Cultural Adaptation in "Highland Civilizations"
  • High Altitude Medical Advice for Travelers
  • Convergent Evolution Observed in Human Adaptation to High Altitude
  • CWRU researcher finds different genes result in same adaptation to thin air
  • The New York Times: Scientists Cite Fastest Case of Human Evolution
  • ABC Science: Novel high-altitude adaptation found in Ethiopians
  • Altitude Adaptation And Acute Mountain Sickness
  • Altitude Research Center: Altitude fast facts
  • Living in High Altitudes
  • Adjustments at High Altitude
  • Peru-High-Altitude Adaptations
  • Evolution, Development, and Genomics
  • bioquick News: Study Aids Genetic Understanding of High-Altitude Adaptation
  • Los Angeles Times: Tibetans' genes have quickly adapted to high altitude
  • The Genetics of High-Altitude Living
  • The Guardian: Mutation in key gene allows Tibetans to thrive at high altitude
  • The Challenge of Living at High Altitudes
  • Peru High-Altitude Adaptations
  • High Altitude: What Happens to the Human Body In the "Death Zone"
  • HTH Travel Insurance: Mountain Sickness
  • At high altitude, carbs are the fuel of choice
  • Knight Science Journalism: High altitude adaptation
  • Educated Guesswork: High altitude adaptation, viagra, and you
  • Working At High Altitude Can Be Hazardous
  • High-altitude hypoxia, genetic adaptation, malnutrition, and child stunting
  • Living at High Altitude
  • Outdoor Action Guide to High Altitude: Acclimatization and Illnesses
  • Daily Mail: Tibetans 'evolved to cope with living at high altitudes in less than 3,000 years'
  • RCSI scientists make breakthrough in understanding human adaptation to high altitude environments
  • MassGenomics: Rapid Human Adaptation to High Altitudes
  • e! Science News: Tibetan adaptation to high altitude occurred in less than 3,000 years
  • Altitude Sickness
  • Adapting to High Altitude
  • Biologists identify the molecular basis of high-altitude adaptation in mice
  • Wikivoyage: Altitude sickness
  • TGDaily: Tibetans evolved quickly to deal with altitude
  • Popular Mechanics: Tibetans' Ability to Live at 13,000 Feet
  • The Daily Galaxy: The "Sherpa Phenomenon": Human Evolution at Work
  • The New Zealand Royal Society: Evolution leap may be fastest ever
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