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Title: Ibmx  
Author: World Heritage Encyclopedia
Language: English
Subject: Phosphodiesterase inhibitor, Xanthine
Publisher: World Heritage Encyclopedia


CAS number 28822-58-4 YesY
PubChem 3758
ChemSpider 3627 YesY
DrugBank DB07954
KEGG C13708 YesY
ChEBI CHEBI:34795 YesY
IUPHAR ligand 388
Jmol-3D images Image 1
Molecular formula C10H14N4O2
Molar mass 222.3 g/mol
Appearance White solid
Melting point

199-201 °C

Solubility Soluble in ethanol, DMSO, and methanol
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

IBMX, 3-isobutyl-1-methylxanthine, like other methylated xanthine derivatives, is both a

  1. competitive nonselective phosphodiesterase inhibitor [1] which raises intracellular cAMP, activates PKA, inhibits TNF-alpha [2][3] and leukotriene [4] synthesis, and reduces inflammation and innate immunity [4] and
  2. nonselective adenosine receptor antagonist.[5]

As a phosphodiesterase inhibitor, IBMX has IC50 = 2-50 μM [6] and does not inhibit PDE8 or PDE9.[7]


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