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Title: Icam3  
Author: World Heritage Encyclopedia
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Subject: CLEC4M, CD153, CD109, CD1E, CD25
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Intercellular adhesion molecule 3

PDB rendering based on 1t0p.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CD50; CDW50; ICAM-R
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
Entrez n/a
Ensembl n/a
UniProt n/a
RefSeq (mRNA) n/a
RefSeq (protein) n/a
Location (UCSC) n/a
PubMed search n/a

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a human gene. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response.[1] It functions not only as an adhesion molecule, but also as a potent signalling molecule.[2]


ICAM3 has been shown to interact with EZR[3][4] and Moesin.[4][5]

See also


  1. ^ de Fougerolles AR,  
  2. ^ "Entrez Gene: ICAM3 intercellular adhesion molecule 3". 
  3. ^ Heiska, L; Alfthan K; Grönholm M; Vilja P; Vaheri A; Carpén O (Aug 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". J. Biol. Chem. (UNITED STATES) 273 (34): 21893–900.  
  4. ^ a b Serrador, Juan M; Vicente-Manzanares Miguel, Calvo Javier, Barreiro Olga, Montoya Maria C, Schwartz-Albiez Reinhard, Furthmayr Heinz, Lozano Francisco, Sánchez-Madrid Francisco (Mar 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". J. Biol. Chem. (United States) 277 (12): 10400–9.  
  5. ^ Serrador, J M; Alonso-Lebrero J L, del Pozo M A, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (Sep 1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization". J. Cell Biol. (UNITED STATES) 138 (6): 1409–23.  

Further reading

External links

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