ICD-10 Chapter II: Neoplasms

International Statistical Classification of Diseases and Related Health Problems 10th Revision
Chapter	Blocks	Title
I	A00–B99	Certain infectious and parasitic diseases
II	C00–D48	Neoplasms
III	D50–D89	Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
IV	E00–E90	Endocrine, nutritional and metabolic diseases
V	F00–F99	Mental and behavioural disorders
VI	G00–G99	Diseases of the nervous system
VII	H00–H59	Diseases of the eye and adnexa
VIII	H60–H95	Diseases of the ear and mastoid process
IX	I00–I99	Diseases of the circulatory system
X	J00–J99	Diseases of the respiratory system
XI	K00–K93	Diseases of the digestive system
XII	L00–L99	Diseases of the skin and subcutaneous tissue
XIII	M00–M99	Diseases of the musculoskeletal system and connective tissue
XIV	N00–N99	Diseases of the genitourinary system
XV	O00–O99	Pregnancy, childbirth and the puerperium
XVI	P00–P96	Certain conditions originating in the perinatal period
XVII	Q00–Q99	Congenital malformations, deformations and chromosomal abnormalities
XVIII	R00–R99	Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
XIX	S00–T98	Injury, poisoning and certain other consequences of external causes
XX	V01–Y98	External causes of morbidity and mortality
XXI	Z00–Z99	Factors influencing health status and contact with health services
XXII	U00–U99	Codes for special purposes

The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO).^[1] This page contains ICD-10 Chapter II: Neoplasms.

1 C00–D48 – Neoplasms
2 See also
3 References

C00–D48 – Neoplasms

(C00–C14) Malignant neoplasms, lip, oral cavity and pharynx

(Malignant neoplasm of lip
(Malignant neoplasm of base of tongue
(Malignant neoplasm of other and unspecified parts of tongue
(Malignant neoplasm of gum
(Malignant neoplasm of floor of mouth
(Malignant neoplasm of palate
(Malignant neoplasm of other and unspecified parts of mouth
(Malignant neoplasm of parotid gland
(Malignant neoplasm of other and unspecified major salivary glands
(Malignant neoplasm of tonsil
(Malignant neoplasm of oropharynx
(11) Malignant neoplasm of nasopharynx
(Malignant neoplasm of piriform sinus
(Malignant neoplasm of hypopharynx
(Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx

(C15–C26) Malignant neoplasms, digestive organs

(Malignant neoplasm of Esophagus
(Malignant neoplasm of Stomach
- (Cardia
- (Fundus of stomach
- (Body of stomach
- (Pyloric antrum
- (Pylorus
- (Lesser curvature of stomach, unspecified
- (Greater curvature of stomach, unspecified
- (16.8) Overlapping lesion of stomach
- (Stomach, unspecified
(Malignant neoplasms of small intestine
- (Duodenum
- (Jejunum
- (Ileum
- (Meckel's diverticulum
- (17.8) Overlapping lesion of small intestine
- (Small intestine, unspecified
(Malignant neoplasm of colon
- (Caecum
- (Appendix
- (Ascending colon
- (Hepatic flexure
- (Transverse colon
- (Splenic flexure
- (Descending colon
- (Sigmoid colon
- (18.8) Overlapping lesion of colon
- (Colon, unspecified
(Malignant neoplasm of rectosigmoid junction
(Malignant neoplasm of rectum
(anal canal
(bile ducts
- (Liver cell carcinoma
- (Intrahepatic bile duct carcinoma
- (Hepatoblastoma
- (Angiosarcoma of liver
- (sarcomas of liver
- (carcinomas of liver
- (Liver, unspecified
(Malignant neoplasm of gallbladder
(Malignant neoplasm of other and unspecified parts of biliary tract
(Malignant neoplasm of pancreas
- (Head of pancreas
- (Body of pancreas
- (Tail of pancreas
- (Pancreatic duct
- (Endocrine pancreas
- (pancreas
- (pancreas
- (Pancreas, unspecified
(Digestive Organs

(C30–C39) Malignant neoplasms, respiratory system and intrathoracic organs

(middle ear
- (Nasal cavity
- (Middle ear
(Malignant neoplasm of accessory sinuses
(Malignant neoplasm of larynx
(trachea
(Malignant neoplasm of bronchus and lung
- (Main bronchus
- (lung
  - Pancoast tumor
- (lung
- (lung
- (lung
(thymus
(pleura
- (Heart
- (Anterior mediastinum
- (Posterior mediastinum
- (Mediastinum, part unspecified
- (Pleura
- (pleura
(intrathoracic organs

(C40–C41) Malignant neoplasms, bone and articular cartilage

(limbs
(articular cartilage of other and unspecified sites

(Note: ICD-10 and ICD-O topography codes are usually the same, but C42 is used in ICD-O but not ICD-10.)^[2]

(C43–C44) Malignant neoplasms, skin

(Skin
(Other malignant neoplasms of skin

(C45–C49) Malignant neoplasms, connective and soft tissue

(Mesothelioma
(Kaposi's Sarcoma
(autonomic nervous system
(peritoneum
- (Retroperitoneum
- (peritoneum
- (Peritoneum, unspecified
(soft tissue
- C49.M10 Malignant fibrous histiocytoma
- C49.M12 Atypical fibroxanthoma
- C49.M20 Haemangiopericytoma
- C49.M22 Angioendotheliomatosis, malignant
- C49.M24 Dermatofibrosarcoma protruberans
- C49.M30 Bednar tumour
- C49.M40 Sarcoma of skin
- C49.M42 Fibrosarcoma
- C49.M44 Schwannoma, malignant
- C49.M48 Leiomyosarcoma
- C49.M50 Rhabdomyosarcoma
- C49.M54 Myxofibrosarcoma
- C49.M60 Angiosarcoma, cutaneous
- C49.M70 Lymphangiosarcoma

(Alphanumeric subcodes are ILDS.)

(C50–C58) Malignant neoplasms, breast and female genital organs

(Malignant neoplasm of breast
(vulva
(Malignant neoplasm of vagina
(Malignant neoplasm of cervix uteri
(Malignant neoplasm of corpus uteri
- (Endometrial cancer
(uterus, part unspecified
(Malignant neoplasm of ovary
(genital organs
(placenta
- Choriocarcinoma
- Chorionepithelioma NOS

(C60–C63) Malignant neoplasms of male genital organs

(Malignant neoplasm of penis
(Malignant neoplasm of prostate
(Malignant neoplasm of testis
(Malignant neoplasm of other and unspecified male genital organs

(C64–C68) Malignant neoplasms, urinary organs

(renal pelvis
- Wilms' tumor
(renal pelvis
(ureter
(Malignant neoplasm of bladder
(urinary organs

(C69–C72) Malignant neoplasms, eye, brain and central nervous system

(Malignant neoplasms of eye and adnexa
- (Conjunctiva
- (Cornea
- (Retina
  - Retinoblastoma
- (Choroid
- (Ciliary body
- (Lacrimal gland and duct
- (Orbit
- (adnexa
(meninges
- (Cerebral meninges
- (Spinal meninges
(Malignant neoplasm of brain
- (Cerebrum, except lobes and ventricles
- (Frontal lobe
- (Temporal lobe
- (Parietal lobe
- (Occipital lobe
- (Cerebral ventricle
- (Cerebellum
- (Brain stem
- (brain
- (Brain, unspecified
(central nervous system
- (Spinal cord
- (Cauda equina
- (Olfactory nerve
- (Optic nerve
- (Acoustic nerve
- (72.5) Other and unspecified cranial nerves
- (central nervous system
- (Central nervous system, unspecified

(C73–C75) Malignant neoplasms, endocrine glands and related structures

(Malignant neoplasm of thyroid gland
(Malignant neoplasm of adrenal gland
- (Cortex of adrenal gland
- (Medulla of adrenal gland
  - Pheochromocytoma
- (Adrenal gland, unspecified
  - Neuroblastoma, NOS
(endocrine glands and related structures

(C76–C80) Malignant neoplasms, secondary and ill-defined

(Malignant neoplasm of other and ill-defined sites
- (Langerhans' cell histiocytosis, not elsewhere classified
- (Haemophagocytic lymphohistiocytosis
- (76.2) Haemophagocytic syndrome, infection-associated
- (histiocytosis syndromes
(lymph nodes
(digestive organs
(malignant neoplasm of other sites
(Malignant neoplasm without specification of site

(C81–C96) Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

(Hodgkin's Disease
- (81.0) Lymphocytic predominance
- (Nodular sclerosis
- (81.2) Mixed cellularity
- (81.3) Lymphocytic depletion
(nodular)
- (Small cleaved cell, follicular
- (82.1) Mixed small cleaved and large cell, follicular
- (Large cell, follicular
(Diffuse non-Hodgkin's lymphoma
- (83.0) Small cell (diffuse)
- (Small cleaved cell (diffuse)
- (83.2) Mixed small and large cell (diffuse)
- (Large cell (diffuse)
- (83.4) Immunoblastic (diffuse)
- (Lymphoblastic (diffuse)
- (83.6) Undifferentiated (diffuse)
- (Burkitt's tumour
(cutaneous T-cell lymphomas
- (Mycosis fungoides
- (Sézary's disease
- (84.2) T-zone lymphoma
- (Lymphoepitheliod lymphoma
- (Peripheral T-cell lymphoma
(non-Hodgkin's lymphoma
- (Lymphosarcoma
- (B-cell lymphoma, unspecified
(immunoproliferative diseases
- (Waldenström's macroglobulinaemia
- (Alpha heavy chain disease
- (Gamma heavy chain disease
- (small intestinal disease
(neoplasms
- (Multiple myeloma
- (leukemia
- (Plasmacytoma, extramedullary
(Lymphoid leukemia
- (Acute lymphoblastic leukemia
- (Chronic lymphocytic leukemia
- (Hairy cell leukemia
(92) Myeloid leukemia
- (Acute myeloid leukemia
- (Chronic myeloid leukemia
- (92.2) Subacute myeloid leukemia
- (Myeloid sarcoma
  - Chloroma
  - Granulocytic sarcoma
- (Acute promyelocytic leukemia
- (Acute myelomonocytic leukemia
(Monocytic leukemia
- (Acute monocytic leukemia
- (Chronic monocytic leukemia
- (93.2) Subacute monocytic leukemia
(leukemias of specified cell type
- (erythroleukemia
  - Di Guglielmo's disease
- (erythraemia
- (Acute megakaryoblastic leukemia
- (Mast cell leukemia
- (panmyelosis
- (myelofibrosis
- (leukemias
(Leukemia of unspecified cell type
- (Acute leukemia of unspecified cell type
- (Chronic leukemia of unspecified cell type
- (95.2) Subacute leukemia of unspecified cell type
- (leukemia of unspecified cell type
- (Leukemia, unspecified
(haematopoietic and related tissue
- (Letterer-Siwe disease
- (Malignant histiocytosis
- (Malignant mast cell tumour
  - Malignant mastocytosis
- (96.3) True histiocytic lymphoma
- (haematopoietic and related tissue
- (haematopoietic and related tissue, unspecified

(C97) Malignant neoplasms of independent (primary) multiple sites

(Malignant neoplasms of independent (primary) multiple sites

(D00–D09) In situ neoplasms

(stomach
(digestive organs
(respiratory system
(in situ
(Carcinoma in situ of skin
(breast
(Carcinoma in situ of cervix uteri
(genital organs
(in situ of other and unspecified sites

(D10–D36) Benign neoplasms

(pharynx
(salivary glands
- Warthin's tumor
- Pleomorphic adenoma
- (Parotid gland
- (salivary glands
  - Sublingual gland
  - Submandibular gland
- (salivary gland, unspecified
(anal canal
- Familial adenomatous polyposis
- (Caecum
- (Appendix
- (Ascending colon
- (Transverse colon
- (Descending colon
- (Sigmoid colon
- (Colon, unspecified
  - Adenomatosis of colon
- (12.7) Rectosigmoid junction
- (Rectum
- (anal canal
(digestive system
- (Oesophagus
- (Stomach
- (Duodenum
- (small intestine
- (Liver
  - Intrahepatic bile ducts
- (Extrahepatic bile ducts
- (Pancreas
- (Endocrine pancreas
  - Islet cell tumour
  - Islets of Langerhans
- (digestive system
  - Digestive system NOS
  - Intestine NOS
  - Spleen
(respiratory system
- (nasal cavity and accessory sinuses
- (Larynx
- (Trachea
- (lung
- (Respiratory system, unspecified
(Benign neoplasm of other and unspecified intrathoracic organs
- (Thymus
- (Heart
  - Myxoma
- (Mediastinum
(articular cartilage
- (upper limb
- (upper limb
- (lower limb
- (lower limb
- (face
- (16.5) Lower jaw bone
- (16.6) Vertebral column
- (clavicle
- (coccyx
- (16.9) Bone and articular cartilage, unspecified
(lipomatous neoplasm
- Lipoma (ILDS D17.910)
- Lipomata, multiple (ILDS D17.920)
- Angiolipoma (ILDS D17.930)
- Lipoblastomatosis (ILDS D17.940)
- Hibernoma (ILDS D17.950)
(lymphangioma, any site
- (Haemangioma, any site
  - Angioma NOS
- (Lymphangioma, any site
  - Cavernous haemangioma (ILDS D18.014)
(mesothelial tissue
(peritoneum
(soft tissue
- Chondroma
- Masson's pseudoangiosarcoma (ILDS D21.M20)
- Synovioma, giant-cell (ILDS D21.M30)
- Leiomyoma (ILDS D21.M40)
- Rhabdomyoma (ILDS D21.M50)
- Angioleiomyoma (ILDS D21.M60)
(Melanocytic naevi
(skin
(breast
(uterus
- Uterine fibroids
(uterus
(ovary
(Benign neoplasm of other and unspecified female genital organs
(Benign neoplasm of male genital organs
(urinary organs
- (Kidney
- (Renal pelvis
- (Ureter
- (Urinary bladder
- (Urethra
- (urinary organs
- (Urinary organ, unspecified
(adnexa
(meninges
(central nervous system
(thyroid gland
(endocrine glands
- (Adrenal gland
- (Parathyroid gland
- (Pituitary gland
  - Pituitary adenoma
  - Prolactinoma
- (Craniopharyngeal duct
- (Pineal gland
- (Carotid body
- (Aortic body and other paraganglia
- (endocrine glands
- (35.8) Pluriglandular involvement
- (Endocrine gland, unspecified
(Benign neoplasm of other and unspecified sites

(D37–D48) Neoplasms of uncertain or unknown behaviour

(digestive organs
(respiratory and intrathoracic organs
(Neoplasm of uncertain or unknown behaviour of female genital organs
- (Uterus
- (Ovary
- (Placenta
- (39.7) Other female genital organs
- (39.9) Female genital organ, unspecified
(Neoplasm of uncertain or unknown behaviour of male genital organs
(urinary organs
(meninges
(central nervous system
(endocrine glands
- (Thyroid gland
- (Adrenal gland
- (Parathyroid gland
- (Pituitary gland
- (Craniopharyngeal duct
- (Pineal gland
- (Carotid body
- (Aortic body and other paraganglia
- (44.8) Pluriglandular involvement
  - Multiple endocrine adenomatosis
- (Endocrine gland, unspecified
(Polycythaemia vera
(Myelodysplastic syndromes
(haematopoietic and related tissue
- (mast cell tumours of uncertain and unknown behaviour
  - Mast cell tumour NOS
  - Mastocytoma NOS
- (myeloproliferative disease
  - Myelofibrosis (with myeloid metaplasia)
  - Myeloproliferative disease, unspecified
  - Myelosclerosis (megakaryocytic) with myeloid metaplasia
- (Monoclonal gammopathy
- (thrombocythaemia
- (haematopoietic and related tissue
- (haematopoietic and related tissue, unspecified
(Neoplasm of uncertain or unknown behaviour of other and unspecified sites
- (articular cartilage
- (soft tissue
- (autonomic nervous system
- (Retroperitoneum
- (Peritoneum
- (Skin
- (Breast
- (48.7) Other specified sites
- (Neoplasm of uncertain or unknown behaviour, unspecified

References

Pathology: Medical conditions and ICD code

(Disease / Disorder / Syndrome / Sequence, Symptom / Sign, Injury, etc.)

(A/B, 001–139)

Infectious disease/Infection: Bacterial disease (G+, G-) · Virus disease · Parasitic disease (Protozoan infection, Helminthiasis, Ectoparasitic infestation) · Mycosis · Zoonosis

(C/D,
140–239 &
279–289)

Cancer (C00–D48, 140–239)	Tumor

Myeloid hematologic (D50–D77, 280–289)	Anemia · Coagulopathy

Lymphoid immune (D80–D89, 279)	Immunodeficiency · Immunoproliferative disorder · Hypersensitivity

(E, 240–278)

Endocrine disease · Nutrition disorder · Inborn error of metabolism

(F, 290–319)

Mental disorder

(G, 320–359)

Nervous system disease (CNS, PNS) · Neuromuscular disease

(H, 360–389)

Eye disease · Ear disease

(I, 390–459)

Cardiovascular disease (Heart disease, Vascular disease)

(J, 460–519)

Respiratory disease (Obstructive lung disease, Restrictive lung disease, Pneumonia)

(K, 520–579)

Oral and maxillofacial pathology (Tooth disease, salivary gland disease, tongue disease) · Digestive disease (Esophageal, Stomach, Enteropathy, Liver, Pancreatic)

(L, 680–709)

Skin disease · skin appendages (Nail disease, Hair disease, Sweat gland disease)

(M, 710–739)

Musculoskeletal disorders: Myopathy · Arthropathy · Osteochondropathy (Osteopathy, Chondropathy)

(N, 580–629)

Urologic disease (Nephropathy, Urinary bladder disease) · Male genital disease · Breast disease · Female genital disease

(O, 630–679)

Complications of pregnancy · Obstetric labor complication · Puerperal disorder

(P, 760–779)

Fetal disease

(Q, 740–759)

Congenital disorder (Congenital abnormality)

(R, 780–799)

Syndromes · Medical signs (Eponymous)

(S/T, 800–999)

Bone fracture · Joint dislocation · Sprain · Strain · Subluxation · Head injury · Chest trauma · Poisoning

Tumors of lip, oral cavity and pharynx / head and neck cancer (C00–C14/D10–D11, 140–149/210)

Oral cancer

Salivary gland	malignant epithelial tumors (Acinic cell carcinoma, Mucoepidermoid carcinoma, Adenoid cystic carcinoma, Salivary duct carcinoma, Epithelial-myoepithelial carcinoma, Polymorphous low-grade adenocarcinoma, Hyalinizing clear cell carcinoma) benign epithelial tumors (Pleomorphic adenoma, Warthin's tumor) ungrouped: Oncocytoma

Tongue	Leukoplakia · Rhabdomyoma

Oropharynx

M: MOU

anat/devp

noco/cofa (c)/cogi/tumr, sysi

proc (peri), drug (A1)

Tumors: digestive system neoplasia (C15–C26/D12–D13, 150–159/211)

GI tract

Upper GI tract

Esophagus	Squamous cell carcinoma Adenocarcinoma

Stomach	Gastric carcinoma Signet ring cell carcinoma Gastric lymphoma MALT lymphoma Linitis plastica

Lower GI tract

Small intestine	Duodenal cancer Adenocarcinoma

Appendix	Carcinoid Pseudomyxoma peritonei

Colon/rectum	colorectal polyp: Peutz–Jeghers syndrome Juvenile polyposis syndrome Familial adenomatous polyposis/Gardner's syndrome Cronkhite–Canada syndrome neoplasm: Adenocarcinoma Familial adenomatous polyposis Hereditary nonpolyposis colorectal cancer

Anus	Squamous cell carcinoma

Upper and/or lower

Accessory

Liver	malignant: Hepatocellular carcinoma Fibrolamellar Hepatoblastoma benign: Hepatocellular adenoma Cavernous hemangioma hyperplasia: Focal nodular hyperplasia Nodular regenerative hyperplasia

Biliary tract	bile duct: Cholangiocarcinoma Klatskin tumor gallbladder: Gallbladder cancer

Pancreas	exocrine pancreas: Adenocarcinoma Pancreatic ductal carcinoma cystic neoplasms: Serous microcystic adenoma Intraductal papillary mucinous neoplasm Mucinous cystic neoplasm Solid pseudopapillary neoplasm Pancreatoblastoma

Peritoneum

Primary peritoneal carcinoma
Peritoneal mesothelioma
Desmoplastic small round cell tumor

M: DIG

anat (t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug (A2A/2B/3/4/5/6/7/14/16), blte

Tumors: Mediastinal tumors/Thoracic neoplasm/respiratory neoplasia (C30–C34/D14, 160–163/212.0–212.4)

Upper RT

Nasal cavity: Esthesioneuroblastoma

Nasopharynx: Nasopharyngeal carcinoma; Nasopharyngeal angiofibroma

Larynx: Laryngeal cancer; Laryngeal papillomatosis

Lower RT

Trachea

Tracheal tumor

Lung

Non-small-cell lung carcinoma	Squamous cell carcinoma Adenocarcinoma of the lung (Mucinous cystadenocarcinoma) Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland-like carcinoma of the lung Adenosquamous carcinoma Papillary adenocarcinoma Giant cell carcinoma

Small-cell carcinoma	Combined small-cell carcinoma

Non-carcinoma	Sarcoma Lymphoma Immature teratoma Melanoma

By location	Pancoast tumor Solitary pulmonary nodule Central lung Peripheral lung

Pleura

M: RES

anat (n, x, l, c)/phys/devp

noco (c, p)/cong/tumr, sysi/epon, injr

proc, drug (R1/2/3/5/6/7)

Tumors: Mediastinal tumor: Heart neoplasia (C38.0/D15.1, 164.1/212.7)

Connective tissue neoplasm

Myxoma (Atrial myxoma)
Lipoma

Other Primary

Papillary fibroelastoma
Rhabdomyoma
Angiosarcoma
Teratoma
Cystic tumour of the atrioventricular nodal region

Other

Secondary

M: HRT

anat/phys/devp

noco/cong/tumr, sysi/epon, injr

proc, drug (C1A/1B/1C/1D), blte

Connective tissue neoplasm: Osseous and Chondromatous tumors (ICD-O 9180–9269) (C40–C41/D16, 170/213)

Diaphysis

Myeloid	Multiple myeloma

Epithelial	Adamantinoma

PNET/Ewing family	Ewing's sarcoma

Metaphysis

Osteoblast	Osteoid osteoma · Osteoblastoma Osteoma/osteosarcoma

Chondroblast	Chondroma/ecchondroma/enchondroma (Enchondromatosis, Extraskeletal chondroma) · Chondrosarcoma (Mesenchymal chondrosarcoma, Myxoid chondrosarcoma) Osteochondroma (Osteochondromatosis) Chondromyxoid fibroma

Fibrous	(Peripheral) Ossifying fibroma · Fibrosarcoma

Epiphysis

Chondroblast	Chondroblastoma

Myeloid	Giant cell tumor of bone

Other/ungrouped

Notochord	Chordoma

M: BON/CAR

anat (c/f/k/f, u, t/p, l)/phys/devp/cell

noco/cong/tumr, sysi/epon, injr

proc, drug (M5)

Tumors: Skin neoplasm, Nevi and melanomas (C43/D22, 172/216, ICD-O 8720-8799)

Melanoma

Mucosal melanoma · Superficial spreading melanoma · Nodular melanoma · lentigo (Lentigo maligna/Lentigo maligna melanoma, Acral lentiginous melanoma)

Amelanotic melanoma · Desmoplastic melanoma · Melanoma with features of a Spitz nevus · Melanoma with small nevus-like cells · Polypoid melanoma · Nevoid melanoma

Melanocytic tumors of uncertain malignant potential

Nevus/
melanocytic nevus

Nevus of Ito/Nevus of Ota · Compound nevus · Spitz nevus (Pigmented spindle cell nevus) · Halo nevus · Junctional nevus · Pseudomelanoma

Blue nevus (of Jadassohn–Tièche · Cellular · Epithelioid · Deep penetrating · Amelanotic · Malignant )

Congenital melanocytic nevus (Giant · Medium-sized · Small-sized)

Balloon cell nevus · Dysplastic nevus/Dysplastic nevus syndrome

Acral nevus · Becker's nevus · Benign melanocytic nevus · Nevus spilus

M: INT, SF, LCT

anat/phys/devp

noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

Connective/soft tissue tumors and sarcomas (ICD-O 8800–9059) (C45–C49/D17–D21, 171/214–215)

Not otherwise specified (8800–8809)

Soft tissue sarcoma · Desmoplastic small round cell tumor

Connective tissue neoplasm

Fibromatous (8810–8839)	Fibroma/fibrosarcoma: Dermatofibrosarcoma · Dermatofibrosarcoma protuberans · Desmoplastic fibroma Fibroma/fibromatosis: Aggressive infantile fibromatosis · Aponeurotic fibroma · Collagenous fibroma · Diffuse infantile fibromatosis · Familial myxovascular fibromas · Fibroma of tendon sheath · Fibromatosis colli · Infantile digital fibromatosis · Juvenile hyaline fibromatosis · Plantar fibromatosis · Pleomorphic fibroma · Oral submucous fibrosis Histiocytoma/histiocytic sarcoma: Benign fibrous histiocytoma · Malignant fibrous histiocytoma · Atypical fibroxanthoma Solitary fibrous tumor

Myxomatous (8840–8849)	Myxoma/myxosarcoma (Cutaneous myxoma, Superficial acral fibromyxoma) · Angiomyxoma · Ossifying fibromyxoid tumour

Fibroepithelial (9000–9039)	Brenner tumour · Fibroadenoma · Phyllodes tumor

Synovial-like (9040–9049)	Synovial sarcoma · Clear-cell sarcoma

Lipomatous (8850–8889)

Lipoma/liposarcoma (Myelolipoma, Myxoid liposarcoma) · PEComa (Angiomyolipoma)

Chondroid lipoma · Intradermal spindle cell lipoma · Pleomorphic lipoma · Benign lipoblastomatosis · Spindle cell lipoma · Hibernoma

Myomatous (8890–8929)

general: Myoma/myosarcoma

smooth muscle: Leiomyoma/leiomyosarcoma

skeletal muscle: Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma (Sarcoma botryoides) · Alveolar rhabdomyosarcoma

Leiomyoma · Angioleiomyoma · Angiolipoleiomyoma · Genital leiomyoma · Leiomyosarcoma · Multiple cutaneous and uterine leiomyomatosis syndrome · Multiple cutaneous leiomyoma · Neural fibrolipoma · Solitary cutaneous leiomyoma · STUMP

Complex mixed and stromal (8930–8999)

Adenomyoma · Pleomorphic adenoma · Mixed Müllerian tumor · Mesoblastic nephroma · Wilms' tumor · Rhabdoid tumour · Clear-cell sarcoma of the kidney · Hepatoblastoma · Pancreatoblastoma · Carcinosarcoma

Mesothelial (9050–9059)

Mesothelioma · Adenomatoid tumor

see also Template:Connective tissue

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco (m, s, c)/cong (d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

Vascular tissue neoplasm (ICD-O 9120–9179) (C49+C46/D18, 171+176/215)

Blood

Lymphatic

Either

M: VAS

anat (a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug (C2s+n/3/4/5/7/8/9)

Tumors: breast cancer (C50/D24, 174–175/217) – Histopathologic classification

Fibroepithelial/stromal

Phyllodes tumor

Ductal, lobular, and medullary

Ductal	Ductal carcinoma in situ (DCIS): Paget's disease of the breast Comedocarcinoma Invasive ductal carcinoma (IDC) Intraductal papilloma

Lobular	Lobular carcinoma in situ (LCIS) Invasive lobular carcinoma (ILC)

Medullary	Medullary carcinoma

Other/ungrouped	Inflammatory breast cancer

Precursor lesions

Atypical ductal hyperplasia

Other

Nipple adenoma

Related subjects

Main article
Classification
Risk factors (Alcohol, Hereditary breast—ovarian cancer syndrome, BRCA mutation)
Screening
Treatment

M: BRE

anat/phys/devp

noco/cong/tumr

proc

Tumors: female urogenital neoplasia (C51–C58/D25–D28, 179–184/218–221)

Adnexa

Ovaries

Glandular and epithelial/ surface epithelial- stromal tumor	CMS: Ovarian serous cystadenoma · Mucinous cystadenoma · Cystadenocarcinoma (Papillary serous cystadenocarcinoma) · Krukenberg tumor Endometrioid tumor · Clear-cell ovarian carcinoma · Brenner tumour

Sex cord-gonadal stromal	Leydig cell tumour · Sertoli cell tumour · Sertoli-Leydig cell tumour · Thecoma · Granulosa cell tumour · Luteoma · Sex cord tumour with annular tubules

Germ cell	Dysgerminoma · Nongerminomatous (Embryonal carcinoma, Endodermal sinus tumor, Gonadoblastoma, Teratoma/Struma ovarii, Choriocarcinoma)

Fibroma	Meigs syndrome

Fallopian tube

Adenomatoid tumor

Uterus

Myometrium	Uterine fibroids/leiomyoma · Leiomyosarcoma · Adenomyoma

Endometrium	Endometrioid tumor · Uterine papillary serous carcinoma · Clear cell carcinoma · Endometrial intraepithelial neoplasia

Cervix	Cervical intraepithelial neoplasia · SCC · Glassy cell carcinoma · Villoglandular adenocarcinoma

Placenta	Choriocarcinoma · Gestational trophoblastic disease

General	Uterine sarcoma · Mixed Müllerian tumor

Vagina

SCC · Botryoid rhabdomyosarcoma · Clear cell adenocarcinoma of the vagina · Vaginal intraepithelial neoplasia

Vulva

SCC · Melanoma · Papillary hidradenoma · Extramammary Paget's disease · Vulvar intraepithelial neoplasia

M: ♀ FRS

anat/phys/devp

noco/cong/npls, sysi/epon

proc/asst, drug (G1/G2B/G3CD)

Tumors: male urogenital neoplasia · genital neoplasia (C60–C63/D29, 185–187/222)

Internal

Testicles

Sex cord-
gonadal stromal

Sertoli-Leydig cell tumour
- Sertoli cell tumour
- Leydig cell tumour

Germ cell

G	Seminoma Spermatocytic seminoma Intratubular germ cell neoplasia

NG	Embryonal carcinoma Endodermal sinus tumor Gonadoblastoma Teratoma Choriocarcinoma Embryoma

Prostate

External

Penis	Carcinoma Extramammary Paget's disease Bowen's disease Bowenoid papulosis Erythroplasia of Queyrat Hirsuties coronae glandis

M: ♂ MRS

anat/phys/devp

noco/cong/tumr, sysi/epon

proc, drug (G3B/4BE/4C)

Tumors: urogenital neoplasia: urinary organs (C64–C68/D30, 188–189/223)

Abdominal

Kidney	Glandular and epithelial neoplasm: Renal cell carcinoma · Renal oncocytoma Complex and mixed tumor: Wilms' tumor · Mesoblastic nephroma · Clear-cell sarcoma of the kidney · Angiomyolipoma · Cystic nephroma · Metanephric adenoma by location: Renal medullary carcinoma · Juxtaglomerular cell tumor · Renal medullary fibroma

Ureter	Ureteral neoplasm

Pelvic

Bladder	Transitional cell carcinoma · Inverted papilloma · Squamous cell carcinoma

Urethra	Transitional cell carcinoma · Squamous cell carcinoma · Adenocarcinoma · Melanoma

Retroperitoneum

Malignant fibrous histiocytoma

M: URI

anat/phys/devp/cell

noco/acba/cong/tumr, sysi/epon, urte

proc/itvp, drug (G4B), blte, urte

Eye neoplasm (C69/D31, 190/224)

Melanoma

Other

M: EYE

anat (g/a/p)/phys/devp/prot

noco/cong/tumr, epon

proc, drug (S1A/1E/1F/1L)

Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350–9589) (C70–C72, D32–D33, 191–192/225)

Endocrine/
sellar (9350–9379)

sellar: Craniopharyngioma · Pituicytoma

other: Pinealoma

CNS
(9380–9539)

Neuroepithelial
(brain tumors,
spinal tumors)

Glioma

Astrocyte	Astrocytoma (Pilocytic astrocytoma, Pleomorphic xanthoastrocytoma, Fibrillary (also diffuse or lowgrade) astrocytomas, Anaplastic astrocytoma, Glioblastoma multiforme)

Oligodendrocyte	Oligodendroglioma

Ependyma	Ependymoma · Subependymoma

Choroid plexus	Choroid plexus tumor (Choroid plexus papilloma, Choroid plexus carcinoma)

Multiple/unknown	Oligoastrocytoma · Gliomatosis cerebri · Gliosarcoma

Mature
neuron

Ganglioneuroma: Ganglioglioma · Retinoblastoma · Neurocytoma · Dysembryoplastic neuroepithelial tumour · Lhermitte-Duclos disease

PNET

Neuroblastoma (Esthesioneuroblastoma, Ganglioneuroblastoma) · Medulloblastoma · Atypical teratoid rhabdoid tumor

Primitive

Medulloepithelioma

Meningiomas
(meninges)

Meningioma, Hemangiopericytoma

Hematopoietic

Primary central nervous system lymphoma

PNS: NST
(9540–9579)

cranial and paraspinal nerves: Neurofibroma (Neurofibrosarcoma, Neurofibromatosis) · Neurilemmoma/Schwannoma (Acoustic neuroma) · Malignant peripheral nerve sheath tumor

note: not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see brain metastases)

M: CNS

anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug (N1A/2AB/C/3/4/7A/B/C/D)

M: PNS

anat (h/r/t/c/b/l/s/a)/phys (r)/devp/prot/nttr/nttm/ntrp

noco/auto/cong/tumr, sysi/epon, injr

proc, drug (N1B)

Tumors: endocrine gland neoplasia (C73–C75/D34–D35, 193–194/226–227)

Pancreas/
islets of Langerhans

neuroendocrine tumors/islet cell carcinoma: α: Glucagonoma
β: Insulinoma
δ: Somatostatinoma
G: Gastrinoma
VIPoma

Hypothalamic/
pituitary axes
+parathyroid

Pituitary	Pituitary adenoma: Prolactinoma ACTH-secreting pituitary adenoma GH-secreting pituitary adenoma Craniopharyngioma Pituicytoma

Thyroid	Thyroid cancer (malignant): epithelial cell carcinoma Papillary Follicular/Hurthle cell parafollicular cell Medullary Anaplastic Lymphoma Squamous cell carcinoma Benign: Thyroid adenoma Struma ovarii

Parathyroid	Parathyroid adenoma Parathyroid carcinoma

Adrenal tumor	adrenal cortex Adrenocortical adenoma Adrenocortical carcinoma adrenal medulla Pheochromocytoma Neuroblastoma see also: Paraganglioma

Gonads	see genital neoplasia

Pinealoma

MEN

M: END

anat/phys/devp/horm

noco (d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)

Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)

B cell
(lymphoma,
leukemia)
(most CD19

CD20)

By development/
marker

TdT+	ALL (Precursor B acute lymphoblastic leukemia/lymphoma)

CD5+	naive B cell (CLL/SLL) mantle zone (Mantle cell)

CD22+	Prolymphocytic CD11c+ (Hairy cell leukemia)

CD79a+	germinal center/follicular B cell (Follicular Burkitt's GCB DLBCL Primary cutaneous follicular lymphoma) marginal zone/marginal-zone B cell (Splenic marginal zone MALT Nodal marginal zone Primary cutaneous marginal zone lymphoma)

RS (CD15+, CD30+)	Classic Hodgkin's lymphoma (Nodular sclerosis) CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)

PCDs/PP (CD38+/CD138+)	see immunoproliferative immunoglobulin disorders

By infection

KSHV (Primary effusion)
EBV (Lymphomatoid granulomatosis
Post-transplant lymphoproliferative disorder)
HIV (AIDS-related lymphoma)
Helicobacter pylori (MALT lymphoma)

Cutaneous

T/NK

T cell
(lymphoma,
leukemia)
(most CD3

CD4
CD8)

By development/
marker

TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)

prolymphocyte (Prolymphocytic)

Cutaneous

MF+variants	indolent: Mycosis fungoides Pagetoid reticulosis Granulomatous slack skin aggressive: Sézary's disease Adult T-cell leukemia/lymphoma

Non-MF	CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma Pleomorphic T-cell lymphoma Lymphomatoid papulosis type B CD30+: CD30+ cutaneous T-cell lymphoma Secondary cutaneous CD30+ large cell lymphoma Lymphomatoid papulosis type A

Other peripheral

Hepatosplenic
Angioimmunoblastic
Enteropathy-associated T-cell lymphoma
Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
Subcutaneous T-cell lymphoma

By infection

HTLV-1 (Adult T-cell leukemia/lymphoma)

NK cell/
(most CD56)

T or NK

Lymphoid+myeloid

Acute biphenotypic leukaemia

Lymphocytosis

Cutaneous lymphoid hyperplasia

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ICD-10 Chapter II: Neoplasms