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Ilf2

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Ilf2

Interleukin enhancer binding factor 2
Identifiers
Symbols  ; NF45; PRO3063
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[1][2] Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[2]

Interactions

ILF2 has been shown to interact with CDC5L[3] and DNA-PKcs.[4]

References

  1. ^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthesy B (September 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". J Biol Chem 269 (32): 20691–9.  
  2. ^ a b "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa". 
  3. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81.  
  4. ^ Ting, N S; Kao P N; Chan D W; Lintott L G; Lees-Miller S P (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol. Chem. (UNITED STATES) 273 (4): 2136–45.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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