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Title: Irak1  
Author: World Heritage Encyclopedia
Language: English
Subject: Signal transduction, Toll-like receptor, Mothers against decapentaplegic homolog 7, MYD88, Xq28, Serine/threonine-specific protein kinase, IKBKG, Immunologic adjuvant, TRAF6, IKK2
Publisher: World Heritage Encyclopedia


Interleukin-1 receptor-associated kinase 1
RNA expression pattern

Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene.[1][2]

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3]


IRAK1 has been shown to interact with Myd88,[4][5][6][7] IKBKG,[8][9] IKK2,[9][10] TRAF6,[1][5][6][11][12][13][14][15][16] CHUK[9][10] and Ubiquitin C.[8][9][17][18]


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