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Interferon gamma receptor 1

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Title: Interferon gamma receptor 1  
Author: World Heritage Encyclopedia
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Subject: CCR8 (gene), Interleukin 5 receptor alpha subunit, C-C chemokine receptor type 6, Interleukin 8 receptor, alpha, CXCR3
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Interferon gamma receptor 1

Interferon gamma receptor 1

PDB rendering based on 1fg9.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CD119; IFNGR
External IDs ChEMBL: GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a human gene.[1][2][3]


IFNGR1 encodes the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2 encodes the non-ligand-binding partner of the heterodimeric receptor.[1]


Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.[4][5]

See also


  1. ^ a b "Entrez Gene: IFNGR1 interferon gamma receptor 1". 
  2. ^ Novick D, Orchansky P, Revel M, Rubinstein M (June 1987). "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". J. Biol. Chem. 262 (18): 8483–7.  
  3. ^ Aguet M, Dembić Z, Merlin G (October 1988). "Molecular cloning and expression of the human interferon-gamma receptor". Cell 55 (2): 273–80.  
  4. ^ Thiel, D J; le Du M H, Walter R L, D'Arcy A, Chène C, Fountoulakis M, Garotta G, Winkler F K, Ealick S E (September 2000). "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex". Structure (ENGLAND) 8 (9): 927–36.  
  5. ^ Kotenko, S V; Izotova L S; Pollack B P; Mariano T M; Donnelly R J; Muthukumaran G; Cook J R; Garotta G; Silvennoinen O; Ihle J N (September 1995). "Interaction between the components of the interferon gamma receptor complex". J. Biol. Chem. (UNITED STATES) 270 (36): 20915–21.  

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