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Interleukin-4 receptor

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Title: Interleukin-4 receptor  
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Subject: Type I cytokine receptor, CXCR6, CCR9, IL3RA, C-C chemokine receptor type 7
Collection: Clusters of Differentiation, Protein Domains, Type I Cytokine Receptors
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Interleukin-4 receptor

Interleukin 4 receptor

PDB rendering based on 1iar.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CD124; IL-4RA; IL4RA
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search
Interleukin-4 receptor alpha chain, N-terminal
interleukin-4 / receptor alpha chain complex
Identifiers
Symbol IL4Ra_N
Pfam PF09238
InterPro IPR015319
SCOP 1iar
SUPERFAMILY 1iar

The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

Contents

  • Function 1
  • Interactions 2
  • Structure 3
  • See also 4
  • References 5
  • Further reading 6
  • External links 7

Function

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.[1]

The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Alternatively activated macrophages (AAMΦ) downregulate inflammatory mediators such as IFNγ during immune responses, particularly with regards to helminth infections.[2]

Interactions

Interleukin-4 receptor has been shown to interact with SHC1.[3][4]

Structure

The N-terminal (extracellular) portion of interleukin-4 receptor is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.[5]

See also

References

  1. ^ "Entrez Gene: IL4R interleukin 4 receptor". 
  2. ^ Tundup S, Srivastava L, Harn DA (April 2012). "Polarization of host immune responses by helminth-expressed glycans". Ann. N. Y. Acad. Sci. 1253: E1–E13.  
  3. ^ Ikizawa K, Yanagihara Y (February 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. 268 (1): 54–9.  
  4. ^ Kashiwada M, Giallourakis CC, Pan PY, Rothman PB (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. 167 (11): 6382–7.  
  5. ^ Hage T, Sebald W, Reinemer P (April 1999). "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface". Cell 97 (2): 271–81.  

Further reading

  • Nelms K, Keegan AD, Zamorano J, et al. (1999). "The IL-4 receptor: signaling mechanisms and biologic functions.". Annu. Rev. Immunol. 17 (1): 701–38.  
  • Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70.  

External links

This article incorporates text from the public domain Pfam and InterPro IPR015319

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