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Interleukin 10 receptor, alpha subunit

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Title: Interleukin 10 receptor, alpha subunit  
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Interleukin 10 receptor, alpha subunit

Interleukin 10 receptor, alpha

PDB rendering based on 1j7v.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. IL10RA, is its human gene.

IL10RA has also recently been designated CDW210A (cluster of differentiation W210A). The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.[1]

Interactions

Interleukin 10 receptor, alpha subunit has been shown to interact with Interleukin 10[2][3][4][5][6] and Janus kinase 1.[7][8]

References

  1. ^ "Entrez Gene: IL10RA interleukin 10 receptor, alpha". 
  2. ^ Ho, A S; Liu Y; Khan T A; Hsu D H; Bazan J F; Moore K W (December 1993). "A receptor for interleukin 10 is related to interferon receptors".  
  3. ^ Josephson, K; Logsdon N J; Walter M R (July 2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity (United States) 15 (1): 35–46.  
  4. ^ Tan, J C; Braun S; Rong H; DiGiacomo R; Dolphin E; Baldwin S; Narula S K; Zavodny P J; Chou C C (May 1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. (UNITED STATES) 270 (21): 12906–11.  
  5. ^ Josephson, K; McPherson D T; Walter M R (December 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D Biol. Crystallogr. (Denmark) 57 (Pt 12): 1908–11.  
  6. ^ Hoover, D M; Schalk-Hihi C; Chou C C; Menon S; Wlodawer A; Zdanov A (May 1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. (GERMANY) 262 (1): 134–41.  
  7. ^ Usacheva, Anna; Sandoval Raudel; Domanski Paul; Kotenko Sergei V; Nelms Keats; Goldsmith Mark A; Colamonici Oscar R (December 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation". J. Biol. Chem. (United States) 277 (50): 48220–6.  
  8. ^ Usacheva, Anna; Kotenko Sergei; Witte Michael M; Colamonici Oscar R (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. (United States) 169 (3): 1302–8.  

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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