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Jun dimerization protein

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Title: Jun dimerization protein  
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Subject: NeuroD, EMX homeogene, NOBOX, Nur (biology), Winged-helix transcription factors
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Jun dimerization protein

Jun dimerization protein 2
Symbols  ; JUNDM2
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Jun dimerization protein 2 is a protein that in humans is encoded by the JDP2 gene.[1][2][3][4]

The Jun dimerization protein is a member of the AP-1 family of transcription factors.[2]


  • Interactions 1
  • References 2
  • Further reading 3
  • External links 4


JDP2 (gene) has been shown to interact with Activating transcription factor 2.[5]


  1. ^ Jin C, Li H, Murata T, Sun K, Horikoshi M, Chiu R, Yokoyama KK (Jun 2002). "JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells". Mol Cell Biol 22 (13): 4815–26.  
  2. ^ a b Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M (Jun 1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Mol Cell Biol 17 (6): 3094–102.  
  3. ^ Stewart M, Mackay N, Hanlon L, Blyth K, Scobie L, Cameron E, Neil JC (Jun 2007). "Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas". Cancer Res 67 (11): 5126–33.  
  4. ^ "Entrez Gene: JDP2 jun dimerization protein 2". 
  5. ^ Murata, Takehide; Shinozuka Yoriko; Obata Yuichi; Yokoyama Kazunari K (May 2008). "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1". Anal. Biochem. (United States) 376 (1): 115–21.  

Further reading

  • Jin C, Ugai H, Song J, et al. (2001). "Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2.". FEBS Lett. 489 (1): 34–41.  
  • Katz S, Heinrich R, Aronheim A (2001). "The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase.". FEBS Lett. 506 (3): 196–200.  
  • Wardell SE, Boonyaratanakornkit V, Adelman JS, et al. (2002). "Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.". Mol. Cell. Biol. 22 (15): 5451–66.  
  • Katz S, Aronheim A (2003). "Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2.". Biochem. J. 368 (Pt 3): 939–45.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Kawaida R, Ohtsuka T, Okutsu J, et al. (2003). "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL.". J. Exp. Med. 197 (8): 1029–35.  
  • Heinrich R, Livne E, Ben-Izhak O, Aronheim A (2004). "The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene.". J. Biol. Chem. 279 (7): 5708–15.  
  • Lerdrup M, Holmberg C, Dietrich N, et al. (2005). "Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis.". Biochim. Biophys. Acta 1745 (1): 29–37.  

External links

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