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Title: Klf6  
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Subject: Jun dimerization protein, Activating transcription factor, WT1, Retinoblastoma protein, P53
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Kruppel-like factor 6
Symbols  ; BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12; ZF9
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.[1]

It is a tumor suppressor gene.[2] This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.[3]


KLF6 has been shown to interact with Sp1 transcription factor.[4]

See also


  1. ^ Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Apr 1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization". Genomics 48 (1): 143–4.  
  2. ^ Li D; Yea S; Dolios G et al. (October 2005). "Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation". Cancer Res. 65 (20): 9216–25.  
  3. ^ "Entrez Gene: KLF6 Kruppel-like factor 6". 
  4. ^ Botella, Luisa M; Sánchez-Elsner Tilman, Sanz-Rodriguez Francisco, Kojima Soichi, Shimada Jun, Guerrero-Esteo Mercedes, Cooreman Michael P, Ratziu Vlad, Langa Carmen, Vary Calvin P H, Ramirez Jose R, Friedman Scott, Bernabéu Carmelo (Dec 2002). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood (United States) 100 (12): 4001–10.  

Further reading

External links

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