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Title: Lhx3  
Author: World Heritage Encyclopedia
Language: English
Subject: Homeobox, Hypopituitarism
Publisher: World Heritage Encyclopedia


LIM homeobox 3
LHX3 Gene
RNA expression pattern

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.[1][2][3]


LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

Clinical significance

Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.[3]


LHX3 has been shown to interact with Ldb1.[4]


Further reading

External links

  • Medical Subject Headings (MeSH)

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