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Limk2

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Limk2

LIM domain kinase 2
PDB rendering based on 1x6a.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.11.1
RNA expression pattern

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.[1][2][3]

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.[3]

References

Further reading


External links

  • Cell Migration Gateway
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